Reactome | LPA-binding receptors bind LPA

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LPA-binding receptors bind LPA Show undefined attributes

authored	[InstanceEdit:419301] Jassal, Bijay, 2009-04-30
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:419301] Jassal, Bijay, 2009-04-30
dbId	419389
displayName	LPA-binding receptors bind LPA
edited	[InstanceEdit:419301] Jassal, Bijay, 2009-04-30
eventOf	[Pathway:R-HSA-419408] Lysosphingolipid and LPA receptors - Homo sapiens
input	[SimpleEntity:R-ALL-417891] LPA [extracellular region] [DefinedSet:R-HSA-419369] LPAR1,2,3,5 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:419326] Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid [LiteratureReference:419312] Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid [LiteratureReference:419407] Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid [LiteratureReference:419391] Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization [LiteratureReference:419373] Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate [LiteratureReference:3249422] Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	LPA-binding receptors bind LPA
orthologousEvent	[Reaction:R-GGA-419389] LPA-binding receptors bind LPA - Gallus gallus [Reaction:R-XTR-419389] LPA-binding receptors bind LPA - Xenopus tropicalis [Reaction:R-DRE-419389] LPA-binding receptors bind LPA - Danio rerio [Reaction:R-SSC-419389] LPA-binding receptors bind LPA - Sus scrofa [Reaction:R-BTA-419389] LPA-binding receptors bind LPA - Bos taurus [Reaction:R-CFA-419389] LPA-binding receptors bind LPA - Canis familiaris [Reaction:R-RNO-419389] LPA-binding receptors bind LPA - Rattus norvegicus [Reaction:R-MMU-419389] LPA-binding receptors bind LPA - Mus musculus
output	[Complex:R-HSA-419353] LPAR1,2,3,5:LPA [plasma membrane]
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422381] D'Eustachio, P, 2009-05-29 07:44:22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-419389
summation	[Summation:419335] The LPA-binding EDG receptors all bind to the ligand lysopho...
updateTrackers	[UpdateTracker:9787309] Update Tracker - [Reaction:419389] LPA-binding receptors bind LPA - v45:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9787309] Update Tracker - [Reaction:419389] LPA-binding receptors bind LPA - v45:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-419408] Lysosphingolipid and LPA receptors

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