Reactome | LPA-binding receptors bind LPA

LPA-binding receptors bind LPA

Stable Identifier

R-HSA-419389

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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The LPA-binding EDG receptors all bind to the ligand lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent signaling molecule.
EDG2 is a human gene encoding a GPCR, LPA1 (as this receptor binds LPA) (An S et al, 1997). Downstream effects such as inhibition of adenylyl cyclase are mediated by binding to Gi proteins (An S et al, 1998).
EDG4 is a human gene which encodes the GPCR known as LPA2 (An S et al, 1998). This protein contributes towards Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins (An S et al, 1998).
EDG7 encodes the GPCR LPA3. This receptor binds LPA and mediates LPA-evoked calcium mobilization. This receptor couples predominantly to Gq/11 alpha proteins (Im DS et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
19366702	Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation Williams, JR, Khandoga, AL, Goyal, P, Fells, JI, Perygin, DH, Siess, W, Parrill, AL, Tigyi, G, Fujiwara, Y	J. Biol. Chem.	2009
10727522	Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate Im, DS, Heise, CE, Harding, MA, George, SR, O'Dowd, BF, Theodorescu, D, Lynch, KR	Mol Pharmacol	2000
9804623	Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization An, S, Bleu, T, Zheng, Y, Goetzl, EJ	Mol Pharmacol	1998
10488122	Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid Bandoh, K, Aoki, J, Hosono, H, Kobayashi, S, Kobayashi, T, Murakami-Murofushi, K, Tsujimoto, M, Arai, H, Inoue, K	J Biol Chem	1999
9070858	Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid An, S, Dickens, MA, Bleu, T, Hallmark, OG, Goetzl, EJ	Biochem Biophys Res Commun	1997
9525886	Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid An, S, Bleu, T, Hallmark, OG, Goetzl, EJ	J Biol Chem	1998