LPA-binding receptors bind LPA

Stable Identifier
Reaction [binding]
Homo sapiens
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The LPA-binding EDG receptors all bind to the ligand lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent signaling molecule.
EDG2 is a human gene encoding a GPCR, LPA1 (as this receptor binds LPA) (An S et al, 1997). Downstream effects such as inhibition of adenylyl cyclase are mediated by binding to Gi proteins (An S et al, 1998).
EDG4 is a human gene which encodes the GPCR known as LPA2 (An S et al, 1998). This protein contributes towards Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins (An S et al, 1998).
EDG7 encodes the GPCR LPA3. This receptor binds LPA and mediates LPA-evoked calcium mobilization. This receptor couples predominantly to Gq/11 alpha proteins (Im DS et al, 2000).
Literature References
PubMed ID Title Journal Year
19366702 Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation

Perygin, DH, Siess, W, Parrill, AL, Khandoga, AL, Fells, JI, Fujiwara, Y, Goyal, P, Tigyi, G, Williams, JR

J. Biol. Chem. 2009
10727522 Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate

Harding, MA, George, SR, O'Dowd, BF, Theodorescu, D, Lynch, KR, Im, DS, Heise, CE

Mol Pharmacol 2000
9804623 Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization

An, S, Goetzl, EJ, Zheng, Y, Bleu, T

Mol Pharmacol 1998
10488122 Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid

Tsujimoto, M, Aoki, J, Kobayashi, T, Arai, H, Murakami-Murofushi, K, Inoue, K, Kobayashi, S, Hosono, H, Bandoh, K

J Biol Chem 1999
9070858 Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid

An, S, Goetzl, EJ, Hallmark, OG, Bleu, T, Dickens, MA

Biochem Biophys Res Commun 1997
9525886 Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid

An, S, Goetzl, EJ, Hallmark, OG, Bleu, T

J Biol Chem 1998
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