Reactome | LPA-binding receptors bind LPA

LPA-binding receptors bind LPA

Stable Identifier

R-HSA-419389

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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The LPA-binding EDG receptors all bind to the ligand lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent signaling molecule.
EDG2 is a human gene encoding a GPCR, LPA1 (as this receptor binds LPA) (An S et al, 1997). Downstream effects such as inhibition of adenylyl cyclase are mediated by binding to Gi proteins (An S et al, 1998).
EDG4 is a human gene which encodes the GPCR known as LPA2 (An S et al, 1998). This protein contributes towards Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins (An S et al, 1998).
EDG7 encodes the GPCR LPA3. This receptor binds LPA and mediates LPA-evoked calcium mobilization. This receptor couples predominantly to Gq/11 alpha proteins (Im DS et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
19366702	Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation Perygin, DH, Siess, W, Parrill, AL, Khandoga, AL, Fells, JI, Fujiwara, Y, Goyal, P, Tigyi, G, Williams, JR	J. Biol. Chem.	2009
10727522	Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate Harding, MA, George, SR, O'Dowd, BF, Theodorescu, D, Lynch, KR, Im, DS, Heise, CE	Mol Pharmacol	2000
9804623	Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization An, S, Goetzl, EJ, Zheng, Y, Bleu, T	Mol Pharmacol	1998
10488122	Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid Tsujimoto, M, Aoki, J, Kobayashi, T, Arai, H, Murakami-Murofushi, K, Inoue, K, Kobayashi, S, Hosono, H, Bandoh, K	J Biol Chem	1999
9070858	Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid An, S, Goetzl, EJ, Hallmark, OG, Bleu, T, Dickens, MA	Biochem Biophys Res Commun	1997
9525886	Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid An, S, Goetzl, EJ, Hallmark, OG, Bleu, T	J Biol Chem	1998