Activation of Rho by LARG and PDZ-RhoGEF

Stable Identifier
R-HSA-416588
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The RhoGEFs LARG and PDZ-RhoGEF complexed with Plexin-B1 stimulate the exchange of GDP for GTP on RhoA through their DH and PH domains.

Literature References
PubMed ID Title Journal Year
12730235 Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

Oinuma, I, Katoh, H, Harada, A, Negishi, M

J Biol Chem 2003
15210733 Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

Swiercz, JM, Kuner, R, Offermanns, S

J Cell Biol 2004
12220504 Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors

Hirotani, M, Ohoka, Y, Yamamoto, T, Nirasawa, H, Furuyama, T, Kogo, M, Matsuya, T, Inagaki, S

Biochem Biophys Res Commun 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Rho guanyl-nucleotide exchange factor activity of SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created