Activation of Rho by LARG and PDZ-RhoGEF

Stable Identifier
R-HSA-416588
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of Rho by LARG and PDZ-RhoGEF
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The RhoGEFs LARG and PDZ-RhoGEF complexed with Plexin-B1 stimulate the exchange of GDP for GTP on RhoA through their DH and PH domains.
Literature References
PubMed ID Title Journal Year
15210733 Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

Swiercz, JM, Kuner, R, Offermanns, S

J Cell Biol 2004
12730235 Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

Oinuma, I, Katoh, H, Harada, A, Negishi, M

J Biol Chem 2003
12220504 Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors

Hirotani, M, Ohoka, Y, Yamamoto, T, Nirasawa, H, Furuyama, T, Kogo, M, Matsuya, T, Inagaki, S

Biochem Biophys Res Commun 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane]

Physical Entity
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of Rho by LARG and PDZ-RhoGEF (Bos taurus)
Activation of Rho by LARG and PDZ-RhoGEF (Caenorhabditis elegans)
Activation of Rho by LARG and PDZ-RhoGEF (Canis familiaris)
Activation of Rho by LARG and PDZ-RhoGEF (Danio rerio)
Activation of Rho by LARG and PDZ-RhoGEF (Drosophila melanogaster)
Activation of Rho by LARG and PDZ-RhoGEF (Gallus gallus)
Activation of Rho by LARG and PDZ-RhoGEF (Mus musculus)
Activation of Rho by LARG and PDZ-RhoGEF (Rattus norvegicus)
Activation of Rho by LARG and PDZ-RhoGEF (Sus scrofa)
Activation of Rho by LARG and PDZ-RhoGEF (Xenopus tropicalis)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kumanogoh, A  (2009-09-02)
Kikutani, H  (2009-09-02)
Created
Garapati, P V  (2009-03-30)
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