Reactome | CCNB:CDK1 phosphorylates BORA

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CCNB:CDK1 phosphorylates BORA Show undefined attributes

authored	[InstanceEdit:3004457] Orlic-Milacic, M, 2013-01-28
catalystActivity	[CatalystActivity:2311326] cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4086408] Orlic-Milacic, M, 2013-08-08
dbId	4086410
displayName	CCNB:CDK1 phosphorylates BORA
edited	[InstanceEdit:3006289] Orlic-Milacic, M, 2013-01-29 [InstanceEdit:9929843] Orlic-Milacic, Marija, 2024-11-28
eventOf	[Pathway:R-HSA-2565942] Regulation of PLK1 Activity at G2/M Transition - Homo sapiens
followingEvent	[Reaction:R-HSA-3000319] BORA binds PLK1 and AURKA - Homo sapiens
input	9 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-2562607] BORA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2565943] Mitotic activation of the kinase Aurora-A requires its binding partner Bora [LiteratureReference:4086413] Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora [LiteratureReference:9929593] Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells [LiteratureReference:9929541] Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CCNB:CDK1 phosphorylates BORA
orthologousEvent	[Reaction:R-CEL-4086410] CCNB:CDK1 phosphorylates BORA - Caenorhabditis elegans [Reaction:R-DME-4086410] CCNB:CDK1 phosphorylates BORA - Drosophila melanogaster [Reaction:R-DRE-4086410] CCNB:CDK1 phosphorylates BORA - Danio rerio [Reaction:R-GGA-4086410] CCNB:CDK1 phosphorylates BORA - Gallus gallus [Reaction:R-XTR-4086410] CCNB:CDK1 phosphorylates BORA - Xenopus tropicalis [Reaction:R-SSC-4086410] CCNB:CDK1 phosphorylates BORA - Sus scrofa [Reaction:R-BTA-4086410] CCNB:CDK1 phosphorylates BORA - Bos taurus [Reaction:R-CFA-4086410] CCNB:CDK1 phosphorylates BORA - Canis familiaris [Reaction:R-RNO-4086410] CCNB:CDK1 phosphorylates BORA - Rattus norvegicus [Reaction:R-MMU-4086410] CCNB:CDK1 phosphorylates BORA - Mus musculus
output	9 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-4086411] p-7S,2T-BORA [cytosol]
precedingEvent	[Reaction:R-HSA-170161] Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B - Homo sapiens [BlackBoxEvent:R-HSA-9929533] CCNA:CDK1 complex translocates to the cytosol - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4410473] Bruinsma, Wytse, 2013-08-21 [InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4086410
summation	[Summation:4086415] CDK1 in complex with cyclin B was shown to phosphorylate bot...
updateTrackers	[UpdateTracker:9939795] Update Tracker - [Reaction:4086410] CCNB:CDK1 phosphorylates BORA - v92:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9939795] Update Tracker - [Reaction:4086410] CCNB:CDK1 phosphorylates BORA - v92:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-2565942] Regulation of PLK1 Activity at G2/M Transition
(precedingEvent)	[Reaction:R-HSA-3000319] BORA binds PLK1 and AURKA

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