Reactome | CDK1 phosphorylates BORA

CDK1 phosphorylates BORA

Stable Identifier

R-HSA-4086410

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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CDK1 phosphorylates both human and Drosophila BORA protein (Hutterer et al. 2006) on an evolutionarily conserved serine residue - S252 in human BORA (Chan et al. 2008), providing a docking site for PLK1.

Literature References

PubMed ID	Title	Journal	Year
16890155	Mitotic activation of the kinase Aurora-A requires its binding partner Bora Hutterer, A, Berdnik, D, Wirtz-Peitz, F, Zigman, M, Schleiffer, A, Knoblich, JA	Dev. Cell	2006
18521620	Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora Chan, EH, Santamaria, A, Silljé, HH, Nigg, EA	Chromosoma	2008