CDK1 phosphorylates BORA

Stable Identifier
R-HSA-4086410
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CDK1 phosphorylates both human and Drosophila BORA protein (Hutterer et al. 2006) on an evolutionarily conserved serine residue - S252 in human BORA (Chan et al. 2008), providing a docking site for PLK1.

Literature References
PubMed ID Title Journal Year
16890155 Mitotic activation of the kinase Aurora-A requires its binding partner Bora

Hutterer, A, Berdnik, D, Wirtz-Peitz, F, Zigman, M, Schleiffer, A, Knoblich, JA

Dev. Cell 2006
18521620 Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora

Chan, EH, Santamaria, A, Silljé, HH, Nigg, EA

Chromosoma 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created