CDK1 phosphorylates BORA

Stable Identifier
R-HSA-4086410
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CDK1 phosphorylates both human and Drosophila BORA protein (Hutterer et al. 2006) on an evolutionarily conserved serine residue - S252 in human BORA (Chan et al. 2008), providing a docking site for PLK1.

Literature References
PubMed ID Title Journal Year
18521620 Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora

Nigg, EA, Chan, EH, Santamaria, A, Silljé, HH

Chromosoma 2008
16890155 Mitotic activation of the kinase Aurora-A requires its binding partner Bora

Hutterer, A, Zigman, M, Knoblich, JA, Schleiffer, A, Wirtz-Peitz, F, Berdnik, D

Dev. Cell 2006
Participants
Participates
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!