CDK1 phosphorylates BORA

Stable Identifier
R-HSA-4086410
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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CDK1 phosphorylates BORA
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CDK1 phosphorylates both human and Drosophila BORA protein (Hutterer et al. 2006) on an evolutionarily conserved serine residue - S252 in human BORA (Chan et al. 2008), providing a docking site for PLK1.

Literature References
PubMed ID Title Journal Year
16890155 Mitotic activation of the kinase Aurora-A requires its binding partner Bora

Hutterer, A, Berdnik, D, Wirtz-Peitz, F, Zigman, M, Schleiffer, A, Knoblich, JA

Dev. Cell 2006
18521620 Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora

Chan, EH, Santamaria, A, Silljé, HH, Nigg, EA

Chromosoma 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
Physical Entity
CCNB1,CCNB2:p-T161-CDK1 [cytosol]
Activity
cyclin-dependent protein serine/threonine kinase activity (0004693)
Orthologous Events
CDK1 phosphorylates BORA (Bos taurus)
CDK1 phosphorylates BORA (Caenorhabditis elegans)
CDK1 phosphorylates BORA (Canis familiaris)
CDK1 phosphorylates BORA (Danio rerio)
CDK1 phosphorylates BORA (Drosophila melanogaster)
CDK1 phosphorylates BORA (Gallus gallus)
CDK1 phosphorylates BORA (Mus musculus)
CDK1 phosphorylates BORA (Rattus norvegicus)
CDK1 phosphorylates BORA (Sus scrofa)
CDK1 phosphorylates BORA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-01-29)
Reviewed
Bruinsma, W  (2013-08-21)
Created
Orlic-Milacic, M  (2013-08-08)