Reactome | BORA binds PLK1 and AURKA

Schema > Reaction > Entries

BORA binds PLK1 and AURKA Show undefined attributes

authored	[InstanceEdit:3004457] Orlic-Milacic, M, 2013-01-28
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3000317] Orlic-Milacic, M, 2013-01-24
dbId	3000319
displayName	BORA binds PLK1 and AURKA
edited	[InstanceEdit:3006289] Orlic-Milacic, M, 2013-01-29 [InstanceEdit:9929534] Orlic-Milacic, Marija, 2024-11-26
eventOf	[Pathway:R-HSA-2565942] Regulation of PLK1 Activity at G2/M Transition - Homo sapiens
followingEvent	[Reaction:R-HSA-3000310] AURKA phosphorylates PLK1 - Homo sapiens
input	[Complex:R-HSA-3000302] Centrosome:p-T288-AURKA [cytosol] [EntityWithAccessionedSequence:R-HSA-4086411] p-7S,2T-BORA [cytosol] [EntityWithAccessionedSequence:R-HSA-164603] PLK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3000320] Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry [LiteratureReference:2565943] Mitotic activation of the kinase Aurora-A requires its binding partner Bora
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	BORA binds PLK1 and AURKA
negativePrecedingEvent	[NegativePrecedingEvent:9764016] Futile Cycle: AURKA phosphorylates PLK1
orthologousEvent	[Reaction:R-GGA-3000319] BORA binds PLK1 and AURKA - Gallus gallus [Reaction:R-XTR-3000319] BORA binds PLK1 and AURKA - Xenopus tropicalis [Reaction:R-SSC-3000319] BORA binds PLK1 and AURKA - Sus scrofa [Reaction:R-BTA-3000319] BORA binds PLK1 and AURKA - Bos taurus [Reaction:R-CFA-3000319] BORA binds PLK1 and AURKA - Canis familiaris [Reaction:R-RNO-3000319] BORA binds PLK1 and AURKA - Rattus norvegicus [Reaction:R-MMU-3000319] BORA binds PLK1 and AURKA - Mus musculus
output	[Complex:R-HSA-3000313] Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol]
precedingEvent	[Reaction:R-HSA-4086410] CCNB:CDK1 phosphorylates BORA - Homo sapiens [Reaction:R-HSA-2574840] AJUBA facilitates AURKA autophosphorylation - Homo sapiens [BlackBoxEvent:R-HSA-4088305] FOXM1 stimulates PLK1 transcription - Homo sapiens [Reaction:R-HSA-9929532] CCNA:CDK1 phosphorylates BORA - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4410473] Bruinsma, Wytse, 2013-08-21 [InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3000319
summation	[Summation:3002850] BORA is able to interact with both AURKA (Aurora A kinase) a...

Referrals

(hasEvent)	[Pathway:R-HSA-2565942] Regulation of PLK1 Activity at G2/M Transition
(precedingEvent)	[Reaction:R-HSA-3000310] AURKA phosphorylates PLK1