Reactome | GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP

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GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP Show undefined attributes

catalystActivity	[CatalystActivity:10284510] UDP-N-acetylglucosamine 2-epimerase activity of GNE hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10284512
displayName	GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP
eventOf	[Pathway:R-CFA-4085001] Sialic acid metabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-4085028] GNE phosphorylates ManNAc to ManNAc-6-P - Canis familiaris
inferredFrom	[Reaction:R-HSA-4085021] GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-162756] UDP-GlcNAc [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP UDP-N-acetyl-alpha-D-glucosamine + H2O => aldehydo-N-acetyl-D-mannosamine + UDP + H(+)
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-4085214] ManNAc [cytosol] [SimpleEntity:R-ALL-110096] UDP [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-4085021
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-4085001] Sialic acid metabolism
(precedingEvent)	[Reaction:R-CFA-4085028] GNE phosphorylates ManNAc to ManNAc-6-P
(inferredTo)	[Reaction:R-HSA-4085021] GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP

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