Reactome | Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells

Schema > BlackBoxEvent > Entries

Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells Show undefined attributes

authored	[InstanceEdit:421433] May, B, 2009-05-18 21:31:59
category	omitted
compartment	[Compartment:984] extracellular region [Compartment:1462052] secretory granule lumen
created	[InstanceEdit:400497] May, B, 2009-03-24 03:41:55
dbId	400509
displayName	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells
edited	[InstanceEdit:435259] May, B, 2009-09-09
eventOf	[Pathway:R-HSA-400511] Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) - Homo sapiens
followingEvent	[Reaction:R-HSA-9023626] DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) - Homo sapiens [Reaction:R-HSA-9023627] DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-400483] GIP(52-93) [secretory granule lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:508114] Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP [LiteratureReference:400491] A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release [LiteratureReference:400463] Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells
orthologousEvent	[BlackBoxEvent:R-GGA-400509] Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells - Gallus gallus [BlackBoxEvent:R-XTR-400509] Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells - Xenopus tropicalis [BlackBoxEvent:R-DRE-400509] Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells - Danio rerio [BlackBoxEvent:R-SSC-400509] Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells - Sus scrofa [BlackBoxEvent:R-BTA-400509] Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells - Bos taurus [BlackBoxEvent:R-CFA-400509] Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells - Canis familiaris [BlackBoxEvent:R-RNO-400509] Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells - Rattus norvegicus [BlackBoxEvent:R-MMU-400509] Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-400540] GIP(52-93) [extracellular region]
precedingEvent	[Reaction:R-HSA-400492] PCSK1 hydrolyzes proGIP to GIP - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-400531] Positive regulation by 'GPR119:monoacylglycerol [plasma membrane]' [PositiveRegulation:R-HSA-416525] Positive regulation by 'FFAR1:FFAR1 ligands [plasma membrane]'
regulationReference	[RegulationReference:9642120] Positive regulation by 'GPR119:monoacylglycerol [plasma membrane]' A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release [RegulationReference:9642853] Positive regulation by 'FFAR1:FFAR1 ligands [plasma membrane]' Biology of incretins: GLP-1 and GIP
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:879883] Bloom, SR, 2010-06-24
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-400509
summation	[Summation:400546] GIP is secreted by intestinal K-cells in response to glucose...

Referrals

(hasEvent)	[Pathway:R-HSA-400511] Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
(precedingEvent)	[Reaction:R-HSA-9023626] DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) [Reaction:R-HSA-9023627] DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)

Cite Us!