Reactome | PCSK1 hydrolyzes proGIP to GIP

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PCSK1 hydrolyzes proGIP to GIP Show undefined attributes

authored	[InstanceEdit:421433] May, B, 2009-05-18 21:31:59
catalystActivity	[CatalystActivity:378987] serine-type endopeptidase activity of PC1:calcium cofactor [secretory granule lumen]
category	transition
compartment	[Compartment:1462052] secretory granule lumen
created	[InstanceEdit:400497] May, B, 2009-03-24 03:41:55
dbId	400492
displayName	PCSK1 hydrolyzes proGIP to GIP
edited	[InstanceEdit:435259] May, B, 2009-09-09
eventOf	[Pathway:R-HSA-400511] Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-400509] Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells - Homo sapiens
inferredFrom	[Reaction:R-MMU-508227] Pcsk1 hydrolyzes ProGip to Gip - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-400526] GIP(22-153) [secretory granule lumen]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCSK1 hydrolyzes proGIP to GIP
output	[EntityWithAccessionedSequence:R-HSA-400483] GIP(52-93) [secretory granule lumen]
precedingEvent	[BlackBoxEvent:R-HSA-421426] ProGIP translocates from the ER Lumen to secretory granules - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:879883] Bloom, SR, 2010-06-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-400492
summation	[Summation:400489] Prohormone Convertase 1/3 in secretory granules cleaves Gluc...
updateTrackers	[UpdateTracker:9787914] Update Tracker - [Reaction:400492] PCSK1 hydrolyzes proGIP to GIP - v44:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9787914] Update Tracker - [Reaction:400492] PCSK1 hydrolyzes proGIP to GIP - v44:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-400511] Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
(precedingEvent)	[BlackBoxEvent:R-HSA-400509] Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells
(inferredTo)	[Reaction:R-MMU-508227] Pcsk1 hydrolyzes ProGip to Gip

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