NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras

Stable Identifier
R-HSA-392054
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
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The guanine nucleotide exchange factor SOS interacts with GRB2 bound to phosphorylated FAK bound to NCAM. Upon formation of this complex, SOS activates Ras by promoting GDP release and GTP binding.

Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Gale, NW, Camonis, JH, Chardin, P, Schlessinger, J, Wigler, MH, Bar-Sagi, D, Van Aelst, L

Science 1993
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane]

Physical Entity
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Bos taurus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Caenorhabditis elegans)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Canis familiaris)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Danio rerio)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Gallus gallus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Rattus norvegicus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Sus scrofa)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Xenopus tropicalis)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Walmod, PS  (2009-05-26)
Maness, PF  (2009-05-26)
Created
Garapati, P V  (2009-02-26)
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