Recruitment of Grb2 to pFAK:NCAM1

Stable Identifier
R-HSA-392051
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment of Grb2 to pFAK:NCAM1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK creates a docking site for the SH2 domain of GRB2 and recruits the GRB2/SOS complex. PTK2 may use this mechanism to activate Ras and the MAP kinase pathway.

Literature References
PubMed ID Title Journal Year
12700044 Cellular signalling mechanisms of neural cell adhesion molecules

Panicker, AK, Buhusi, M, Thelen, K, Maness, PF

Front Biosci 2003
7997267 Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

Schlaepfer, DD, Hanks, SK, Hunter, T, van der Geer, P

Nature 1994
2809592 Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix

Probstmeier, R, Kuhn, K, Schachner, M

J Neurochem 1989
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Recruitment of Grb2 to pFAK:NCAM1 (Bos taurus)
Recruitment of Grb2 to pFAK:NCAM1 (Caenorhabditis elegans)
Recruitment of Grb2 to pFAK:NCAM1 (Canis familiaris)
Recruitment of Grb2 to pFAK:NCAM1 (Danio rerio)
Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)
Recruitment of Grb2 to pFAK:NCAM1 (Rattus norvegicus)
Recruitment of Grb2 to pFAK:NCAM1 (Xenopus tropicalis)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Maness, PF  (2009-05-26)
Walmod, PS  (2009-05-26)
Created
Garapati, P V  (2009-02-26)