Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK creates a docking site for the SH2 domain of GRB2 and recruits the GRB2/SOS complex. PTK2 may use this mechanism to activate Ras and the MAP kinase pathway.
Schlaepfer, DD, van der Geer, P, Hanks, SK, Hunter, T
Panicker, AK, Thelen, K, Buhusi, M, Maness, PF
Kuhn, K, Probstmeier, R, Schachner, M
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