Recruitment of Grb2 to pFAK:NCAM1

Stable Identifier
R-HSA-392051
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Recruitment of Grb2 to pFAK:NCAM1
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Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK creates a docking site for the SH2 domain of GRB2 and recruits the GRB2/SOS complex. PTK2 may use this mechanism to activate Ras and the MAP kinase pathway.
Literature References
PubMed ID Title Journal Year
7997267 Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

Schlaepfer, DD, Hanks, SK, Hunter, T, van der Geer, P

Nature 1994
12700044 Cellular signalling mechanisms of neural cell adhesion molecules

Panicker, AK, Buhusi, M, Thelen, K, Maness, PF

Front Biosci 2003
2809592 Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix

Probstmeier, R, Kuhn, K, Schachner, M

J Neurochem 1989
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Orthologous Events
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Recruitment of Grb2 to pFAK:NCAM1 (Canis familiaris)
Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)
Recruitment of Grb2 to pFAK:NCAM1 (Rattus norvegicus)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Maness, PF  (2009-05-26)
Walmod, PS  (2009-05-26)
Created
Garapati, P V  (2009-02-26)
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