Reactome | p-4Y-SIRPA:CD47 binds PTPN6,PTPN11

Schema > Reaction > Entries

authored	[InstanceEdit:391161] Garapati, P V, 2009-02-12 18:17:40
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:391154] Garapati, P V, 2009-02-12 18:16:59
dbId	391150
displayName	p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
edited	[InstanceEdit:391161] Garapati, P V, 2009-02-12 18:17:40
eventOf	[Pathway:R-HSA-391160] Signal regulatory protein family interactions - Homo sapiens
inferredFrom	[Reaction:R-RNO-548968] Recruitment of Shp-2 to pSirp alpha - Rattus norvegicus [Reaction:R-MMU-548971] Recruitment of Shp-1 to pSirp alpha - Mus musculus
input	[Complex:R-HSA-391115] p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] [DefinedSet:R-HSA-389744] PTPN6,PTPN11 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 Recruitment of SHP-2 and SHP-1 to pSIRP alpha
output	[Complex:R-HSA-391110] p-Y429,Y453,Y470,Y496-SIRPA:PTPN6,PTPN11 [plasma membrane]
precedingEvent	[Reaction:R-HSA-391156] Phosphorylation of ITIM motif in SIRP alpha - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:763969] Barclay, AN, 2010-05-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-391150
summation	[Summation:391056] SIRP alpha functions as a docking protein. The tyrosine-phos...

(hasEvent)	[Pathway:R-HSA-391160] Signal regulatory protein family interactions
(inferredTo)	[Reaction:R-MMU-548971] Recruitment of Shp-1 to pSirp alpha [Reaction:R-RNO-548968] Recruitment of Shp-2 to pSirp alpha

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