p-4Y-SIRPA:CD47 binds PTPN6,PTPN11

Stable Identifier
R-HSA-391150
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
Recruitment of SHP-2 and SHP-1 to pSIRP alpha
ReviewStatus
5/5
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p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
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SIRP alpha functions as a docking protein. The tyrosine-phosphorylated residues of SIRP alpha trigger the binding and activation of tyrosine phosphatases SHP-1 and SHP-2. All four phosphotyrosines of SIRP alpha may serve as substrates for SHP-1 and SHP-2. SIRP alpha binds mostly to SHP-1 in hematopoietic cells and with SHP-2 in non-hematopoietic cells. These phosphatases mediate the specific functions of SIRP alpha.
Participants
Input
Output
Participates
as an event of
Inferred From
Recruitment of Shp-1 to pSirp alpha (Mus musculus)
Recruitment of Shp-2 to pSirp alpha (Rattus norvegicus)
Authored
Garapati, P V  (2009-02-12)
Reviewed
Barclay, AN  (2010-05-20)
Created
Garapati, P V  (2009-02-12)
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