SIRP alpha functions as a docking protein. The tyrosine-phosphorylated residues of SIRP alpha trigger the binding and activation of tyrosine phosphatases SHP-1 and SHP-2. All four phosphotyrosines of SIRP alpha may serve as substrates for SHP-1 and SHP-2. SIRP alpha binds mostly to SHP-1 in hematopoietic cells and with SHP-2 in non-hematopoietic cells. These phosphatases mediate the specific functions of SIRP alpha.
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