Reactome | Signal regulatory protein family interactions

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Signal regulatory protein family interactions Show undefined attributes

authored	[InstanceEdit:391161] Garapati, P V, 2009-02-12 18:17:40
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:391161] Garapati, P V, 2009-02-12 18:17:40
dbId	391160
displayName	Signal regulatory protein family interactions
doi	10.3180/REACT_23752.1
edited	[InstanceEdit:391161] Garapati, P V, 2009-02-12 18:17:40
eventOf	[TopLevelPathway:R-HSA-1500931] Cell-Cell communication - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-391158] SIRP alpha binds CD47 - Homo sapiens [Reaction:R-HSA-391156] Phosphorylation of ITIM motif in SIRP alpha - Homo sapiens [Reaction:R-HSA-391150] p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 - Homo sapiens [Reaction:R-HSA-391157] p-4Y-SIRPA:CD47 binds SKAP2 - Homo sapiens [Reaction:R-HSA-391151] p-4Y-SIRPA:CD47:SKAP2 binds FYB - Homo sapiens [Reaction:R-HSA-391152] p-4Y-SIRPA:CD47 binds PTK2B - Homo sapiens [Reaction:R-HSA-391153] p-4Y-SIRPA:CD47 binds GRB2-1 - Homo sapiens [Reaction:R-HSA-391155] SIRPA binds SFTPA oligomer, SFTPD oligomer - Homo sapiens [Reaction:R-HSA-210274] SIRP beta binds TYROBP - Homo sapiens [Reaction:R-HSA-391168] SIRP gamma binds CD47 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-06-22
literatureReference	[LiteratureReference:203245] The SIRP family of receptors and immune regulation [LiteratureReference:391053] SHPS-1, a multifunctional transmembrane glycoprotein [LiteratureReference:548909] Functions and molecular mechanisms of the CD47-SIRPalpha signalling pathway [LiteratureReference:391140] Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration [LiteratureReference:925201] A nomenclature for signal regulatory protein family members
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Signal regulatory protein family interactions
orthologousEvent	[Pathway:R-GGA-391160] Signal regulatory protein family interactions - Gallus gallus [Pathway:R-SSC-391160] Signal regulatory protein family interactions - Sus scrofa [Pathway:R-BTA-391160] Signal regulatory protein family interactions - Bos taurus [Pathway:R-CFA-391160] Signal regulatory protein family interactions - Canis familiaris [Pathway:R-RNO-391160] Signal regulatory protein family interactions - Rattus norvegicus [Pathway:R-MMU-391160] Signal regulatory protein family interactions - Mus musculus
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:763969] Barclay, AN, 2010-05-20
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-391160
summation	[Summation:391048] Signal regulatory protein alpha (SIRPA, SHPS1, CD172a) is a ...
updateTrackers	[UpdateTracker:9788343] Update Tracker - [Pathway:391160] Signal regulatory protein family interactions - v42:[updateContainedRLE] [UpdateTracker:9787409] Update Tracker - [Pathway:391160] Signal regulatory protein family interactions - v45:[updateContainedRLE] [UpdateTracker:9781397] Update Tracker - [Pathway:391160] Signal regulatory protein family interactions - v61:[modifyText, updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9788343] Update Tracker - [Pathway:391160] Signal regulatory protein family interactions - v42:[updateContainedRLE]
[UpdateTracker:9787409] Update Tracker - [Pathway:391160] Signal regulatory protein family interactions - v45:[updateContainedRLE]
[UpdateTracker:9781397] Update Tracker - [Pathway:391160] Signal regulatory protein family interactions - v61:[modifyText, updateContainedRLE]

(hasEvent)

[TopLevelPathway:R-HSA-1500931] Cell-Cell communication

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