Reactome | glyoxylate + NADPH + H+ => glycolate + NADP+

Schema > Reaction > Entries

glyoxylate + NADPH + H+ => glycolate + NADP+ Show undefined attributes

authored	[InstanceEdit:389673] D'Eustachio, P, 2009-01-11 19:48:01
catalystActivity	[CatalystActivity:389805] glyoxylate reductase (NADPH) activity of GRHPR [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:389814] D'Eustachio, P, 2009-01-17 15:10:12
crossReference	[DatabaseIdentifier:12667699] RHEA:10994 [DatabaseIdentifier:9930616] RHEA:10994
dbId	389826
displayName	glyoxylate + NADPH + H+ => glycolate + NADP+
edited	[InstanceEdit:392437] D'Eustachio, P, 2009-03-03 14:28:53
eventOf	[Pathway:R-HSA-389661] Glyoxylate metabolism and glycine degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-389842] HAO1 tetramer oxidizes glycolate to glyoxylate - Homo sapiens
input	[SimpleEntity:R-ALL-389678] glyoxylate [peroxisomal matrix] [SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-113602] NADPH [peroxisomal matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389846] Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase [LiteratureReference:389837] The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	glyoxylate + NADPH + H+ => glycolate + NADP+ glyoxylate + H(+) + NADPH => glycolate + NADP(+)
orthologousEvent	[Reaction:R-DRE-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Danio rerio [Reaction:R-DME-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Drosophila melanogaster [Reaction:R-DDI-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Dictyostelium discoideum [Reaction:R-GGA-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Gallus gallus [Reaction:R-XTR-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Xenopus tropicalis [Reaction:R-SSC-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Sus scrofa [Reaction:R-BTA-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Bos taurus [Reaction:R-CFA-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Canis familiaris [Reaction:R-RNO-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Rattus norvegicus [Reaction:R-MMU-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Mus musculus
output	[SimpleEntity:R-ALL-389822] glycolate [peroxisomal matrix] [SimpleEntity:R-ALL-389556] NADP+ [peroxisomal matrix]
precedingEvent	[Reaction:R-HSA-389821] glycine + O2 => glyoxylate + H2O2 + NH4+ - Homo sapiens [BlackBoxEvent:R-HSA-6784434] An unknown carrier transports cytosolic glyoxylate to the peroxisome - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392439] Jassal, B, 2009-03-03 14:29:24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389826
summation	[Summation:389840] Peroxisomal GRHPR catalyzes the reaction of glyoxylate and N...

Referrals

(hasEvent)	[Pathway:R-HSA-389661] Glyoxylate metabolism and glycine degradation
(precedingEvent)	[Reaction:R-HSA-389842] HAO1 tetramer oxidizes glycolate to glyoxylate