Reactome | glyoxylate + NADPH + H+ => glycolate + NADP+

Schema > Reaction > Entries

glyoxylate + NADPH + H+ => glycolate + NADP+ Show undefined attributes

catalystActivity	[CatalystActivity:10012928] glyoxylate reductase (NADPH) activity of GRHPR [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10012930
displayName	glyoxylate + NADPH + H+ => glycolate + NADP+
eventOf	[Pathway:R-MMU-389661] Glyoxylate metabolism and glycine degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-389842] HAO1 tetramer oxidizes glycolate to glyoxylate - Mus musculus
inferredFrom	[Reaction:R-HSA-389826] glyoxylate + NADPH + H+ => glycolate + NADP+ - Homo sapiens
input	[SimpleEntity:R-ALL-389678] glyoxylate [peroxisomal matrix] [SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-113602] NADPH [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	glyoxylate + NADPH + H+ => glycolate + NADP+ glyoxylate + H(+) + NADPH => glycolate + NADP(+)
output	[SimpleEntity:R-ALL-389822] glycolate [peroxisomal matrix] [SimpleEntity:R-ALL-389556] NADP+ [peroxisomal matrix]
precedingEvent	[Reaction:R-MMU-389821] glycine + O2 => glyoxylate + H2O2 + NH4+ - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-389826
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-389661] Glyoxylate metabolism and glycine degradation
(precedingEvent)	[Reaction:R-MMU-389842] HAO1 tetramer oxidizes glycolate to glyoxylate
(inferredTo)	[Reaction:R-HSA-389826] glyoxylate + NADPH + H+ => glycolate + NADP+

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