Peroxisomal GRHPR catalyzes the reaction of glyoxylate and NADPH + H+ to form glycolate and NADP+. The active form of the enzyme is a monomer (Rumsby and Cregeen 1999); mutations in it are associated with primary hyperoxaluria type II (Cramer et al. 1999).
Rumsby, G, Cregeen, DP
Cramer, SD, Ferree, PMPM, Lin, K, Milliner, DS, Holmes, RP
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