Peroxisomal GRHPR catalyzes the reaction of glyoxylate and NADPH + H+ to form glycolate and NADP+. The active form of the enzyme is a monomer (Rumsby and Cregeen 1999); mutations in it are associated with primary hyperoxaluria type II (Cramer et al. 1999).
Holmes, RP, Ferree, PMPM, Lin, K, Cramer, SD, Milliner, DS
Rumsby, G, Cregeen, DP
glyoxylate reductase (NADP+) activity of GRHPR [peroxisomal matrix]
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