Reactome | 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA

Schema > Reaction > Entries

2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA Show undefined attributes

authored	[InstanceEdit:389624] D'Eustachio, P, 2009-01-10 20:36:15
catalystActivity	[CatalystActivity:389618] carbon-carbon lyase activity of HACL1 tetramer [peroxisomal matrix]
catalystActivityReference	[CatalystActivityReference:9913869] carbon-carbon lyase activity of HACL1 tetramer [peroxisomal matrix] Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:389592] D'Eustachio, P, 2009-01-10 20:38:44
crossReference	[DatabaseIdentifier:12667725] RHEA:25356 [DatabaseIdentifier:9913868] RHEA:25356
dbId	389611
displayName	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA
edited	[InstanceEdit:389624] D'Eustachio, P, 2009-01-10 20:36:15
eventOf	[Pathway:R-HSA-389599] Alpha-oxidation of phytanate - Homo sapiens
followingEvent	[Reaction:R-HSA-389580] formyl-CoA + H2O => formate + CoASH - Homo sapiens [Reaction:R-HSA-389609] ALDH3A2-2 oxidizes pristanal to pristanate - Homo sapiens
input	[SimpleEntity:R-ALL-389594] 3S2HPhy-CoA [peroxisomal matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389614] Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids [LiteratureReference:389630] Production of formyl-CoA during peroxisomal alpha-oxidation of 3-methyl-branched fatty acids
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA 2-hydroxyphytanoyl-CoA => 2,6,10,14-tetramethylpentadecanal + formyl-CoA
orthologousEvent	[Reaction:R-SCE-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Saccharomyces cerevisiae [Reaction:R-SPO-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Schizosaccharomyces pombe [Reaction:R-DDI-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Dictyostelium discoideum [Reaction:R-CEL-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Caenorhabditis elegans [Reaction:R-DME-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Drosophila melanogaster [Reaction:R-GGA-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Gallus gallus [Reaction:R-XTR-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Xenopus tropicalis [Reaction:R-DRE-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Danio rerio [Reaction:R-SSC-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Sus scrofa [Reaction:R-BTA-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Bos taurus [Reaction:R-CFA-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Canis familiaris [Reaction:R-RNO-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Rattus norvegicus [Reaction:R-MMU-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-389578] FOR-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-389636] Pristanal [peroxisomal matrix]
precedingEvent	[Reaction:R-HSA-389639] phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392190] Jassal, Bijay, 2009-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389611
summation	[Summation:389587] Peroxisomal HACL1 catalyzes the reaction of 2-hydroxyphytano...

Referrals

(hasEvent)	[Pathway:R-HSA-389599] Alpha-oxidation of phytanate
(precedingEvent)	[Reaction:R-HSA-389580] formyl-CoA + H2O => formate + CoASH [Reaction:R-HSA-389609] ALDH3A2-2 oxidizes pristanal to pristanate

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