Reactome | 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA

Schema > Reaction > Entries

2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10934731] carbon-carbon lyase activity of HACL1 tetramer [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10934733
displayName	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA
eventOf	[Pathway:R-CEL-389599] Alpha-oxidation of phytanate - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-389609] ALDH3A2-2 oxidizes pristanal to pristanate - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-389594] 3S2HPhy-CoA [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA 2-hydroxyphytanoyl-CoA => 2,6,10,14-tetramethylpentadecanal + formyl-CoA
output	[SimpleEntity:R-ALL-389578] FOR-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-389636] Pristanal [peroxisomal matrix]
precedingEvent	[Reaction:R-CEL-389639] phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-389611
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-389599] Alpha-oxidation of phytanate
(precedingEvent)	[Reaction:R-CEL-389609] ALDH3A2-2 oxidizes pristanal to pristanate
(inferredTo)	[Reaction:R-HSA-389611] 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA

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