2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA

Stable Identifier
R-HSA-389611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Peroxisomal HACL1 catalyzes the reaction of 2-hydroxyphytanoyl-CoA to form pristanal and formyl-CoA. The active form of the enzyme is a homotetramer, with one Mg++ and one molecule of thiamin pyrophosphate bound to each monomer (Croes et al. 1997; Foulon et al. 1999).

Literature References
PubMed ID Title Journal Year
10468558 Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids

Foulon, V, Antonenkov, VD, Croes, K, Waelkens, E, Mannaerts, GP, Van Veldhoven, PP, Casteels, M

Proc Natl Acad Sci U S A 1999
9166898 Production of formyl-CoA during peroxisomal alpha-oxidation of 3-methyl-branched fatty acids

Croes, K, Van Veldhoven, PP, Mannaerts, GP, Casteels, M

FEBS Lett 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
carbon-carbon lyase activity of HACL1 tetramer [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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