Reactome | 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA

2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA

Stable Identifier

R-HSA-389611

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

2-hydroxyphytanoyl-CoA => 2,6,10,14-tetramethylpentadecanal + formyl-CoA

ReviewStatus

5/5

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2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA

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Peroxisomal HACL1 catalyzes the reaction of 2-hydroxyphytanoyl-CoA to form pristanal and formyl-CoA. The active form of the enzyme is a homotetramer, with one Mg++ and one molecule of thiamin pyrophosphate bound to each monomer (Croes et al. 1997; Foulon et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9166898	Production of formyl-CoA during peroxisomal alpha-oxidation of 3-methyl-branched fatty acids Casteels, M, Van Veldhoven, PP, Mannaerts, GP, Croes, K	FEBS Lett	1997
10468558	Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids Waelkens, E, Casteels, M, Van Veldhoven, PP, Mannaerts, GP, Croes, K, Foulon, V, Antonenkov, VD	Proc Natl Acad Sci U S A	1999