PI3K binds ICOS

Stable Identifier
R-HSA-388830
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
Summation

The p85 unit of PI3K is the only signaling molecule identified so far that interacts with ICOS. ICOS contains several conserved motifs also found in CD28, including the YxxM motif in the cytoplasmic tail, which binds the lipid kinase phosphatidylinositol 3-kinase (PI3K) upon tyrosine phosphorylation after complex formation with ICOS. However, ICOS costimulation shows greater PI3K activity than CD28 in T cells.

Literature References
PubMed ID Title Journal Year
12538664 A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)

Harada, Y, Ohgai, D, Watanabe, R, Okano, K, Koiwai, O, Tanabe, K, Toma, H, Altman, A, Abe, R

J Exp Med 2003
Participants
Input
Output
Participant Of
hasEvent
This entity is regulated by
Positive Regulation
Orthologous Events
PI3K binds ICOS (Bos taurus)
PI3K binds ICOS (Canis familiaris)
PI3K binds ICOS (Gallus gallus)
PI3K binds ICOS (Mus musculus)
PI3K binds ICOS (Rattus norvegicus)
PI3K binds ICOS (Sus scrofa)
PI3K binds ICOS (Taeniopygia guttata)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)