PI3K binds ICOS

Stable Identifier
R-HSA-388830
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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ICOS ligation in T cells triggers the recruitment of PI3K, leading to increased production of PIP3 and stronger AKT phosphorylation compared to CD28 signaling. This enhanced activation is driven by a unique signaling motif in the cytoplasmic tail of ICOS, which enables more effective binding to PI3K components. As a result, ICOS signaling supports robust downstream signaling pathways that are crucial for T cell activation and differentiation, including the promotion of the T follicular helper (Tfh) cell phenotype (Fos et al. 2008).
Literature References
PubMed ID Title Journal Year
12538664 A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)

Tanabe, K, Koiwai, O, Okano, K, Harada, Y, Toma, H, Abe, R, Altman, A, Watanabe, R, Ohgai, D

J Exp Med 2003
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