Reactome | ABC7, mABC1 and mABC2 mediate heme transport

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ABC7, mABC1 and mABC2 mediate heme transport Show undefined attributes

authored	[InstanceEdit:382535] Gopinathrao, G, 2008-11-23 14:00:06
catalystActivity	[CatalystActivity:382512] ABC-type heme transporter activity of Heme transporters [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:70101] cytosol [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:382535] Gopinathrao, G, 2008-11-23 14:00:06
crossReference	[DatabaseIdentifier:12667904] RHEA:19261
dbId	382560
displayName	ABC7, mABC1 and mABC2 mediate heme transport
edited	[InstanceEdit:382535] Gopinathrao, G, 2008-11-23 14:00:06
eventOf	[Pathway:R-HSA-1369007] Mitochondrial ABC transporters - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-189444] heme [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:382534] Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p [LiteratureReference:1369048] The mitochondrial ABC transporter Atm1p functions as a homodimer [LiteratureReference:1369040] Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A) [LiteratureReference:1369039] Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore [LiteratureReference:1369070] Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein [LiteratureReference:1369003] M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein [LiteratureReference:1369051] Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me)
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ABC7, mABC1 and mABC2 mediate heme transport
orthologousEvent	[Reaction:R-SCE-382560] ABC7, mABC1 and mABC2 mediate heme transport - Saccharomyces cerevisiae [Reaction:R-SPO-382560] ABC7, mABC1 and mABC2 mediate heme transport - Schizosaccharomyces pombe [Reaction:R-DDI-382560] ABC7, mABC1 and mABC2 mediate heme transport - Dictyostelium discoideum [Reaction:R-CEL-382560] ABC7, mABC1 and mABC2 mediate heme transport - Caenorhabditis elegans [Reaction:R-DME-382560] ABC7, mABC1 and mABC2 mediate heme transport - Drosophila melanogaster [Reaction:R-GGA-382560] ABC7, mABC1 and mABC2 mediate heme transport - Gallus gallus [Reaction:R-XTR-382560] ABC7, mABC1 and mABC2 mediate heme transport - Xenopus tropicalis [Reaction:R-DRE-382560] ABC7, mABC1 and mABC2 mediate heme transport - Danio rerio [Reaction:R-SSC-382560] ABC7, mABC1 and mABC2 mediate heme transport - Sus scrofa [Reaction:R-BTA-382560] ABC7, mABC1 and mABC2 mediate heme transport - Bos taurus [Reaction:R-CFA-382560] ABC7, mABC1 and mABC2 mediate heme transport - Canis familiaris [Reaction:R-RNO-382560] ABC7, mABC1 and mABC2 mediate heme transport - Rattus norvegicus [Reaction:R-MMU-382560] ABC7, mABC1 and mABC2 mediate heme transport - Mus musculus
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-71185] ferroheme [cytosol] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387472] Matthews, L, 2008-12-02 15:41:53 [InstanceEdit:1502533] D'Eustachio, P, 2011-08-23
revised	[InstanceEdit:1368972] Jassal, Bijay, 2011-07-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-382560
summation	[Summation:387027] Mitochondrial ABC transporters are thought to play a key rol...
updateTrackers	[UpdateTracker:9789075] Update Tracker - [Reaction:382560] ABC7, mABC1 and mABC2 mediate heme transport - v38:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789075] Update Tracker - [Reaction:382560] ABC7, mABC1 and mABC2 mediate heme transport - v38:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-1369007] Mitochondrial ABC transporters

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