Reactome | PDGF binds to extracellular matrix proteins

Schema > Reaction > Entries

PDGF binds to extracellular matrix proteins Show undefined attributes

authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:382060] Garapati, P V, 2008-11-21 20:21:25
dbId	382054
displayName	PDGF binds to extracellular matrix proteins
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
eventOf	[Pathway:R-HSA-186797] Signaling by PDGF - Homo sapiens
input	[DefinedSet:R-HSA-381946] Extracellular matrix ligands [extracellular region] 2 × [DefinedSet:R-HSA-381934] PDGF A and B chains with retention motif [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:380730] Mechanism of action and in vivo role of platelet-derived growth factor [LiteratureReference:382046] Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB) [LiteratureReference:382044] The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors [LiteratureReference:382014] Interaction of platelet-derived growth factor with thrombospondin 1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PDGF binds to extracellular matrix proteins
orthologousEvent	[Reaction:R-DME-382054] PDGF binds to extracellular matrix proteins - Drosophila melanogaster [Reaction:R-CEL-382054] PDGF binds to extracellular matrix proteins - Caenorhabditis elegans [Reaction:R-GGA-382054] PDGF binds to extracellular matrix proteins - Gallus gallus [Reaction:R-XTR-382054] PDGF binds to extracellular matrix proteins - Xenopus tropicalis [Reaction:R-DRE-382054] PDGF binds to extracellular matrix proteins - Danio rerio [Reaction:R-SSC-382054] PDGF binds to extracellular matrix proteins - Sus scrofa [Reaction:R-BTA-382054] PDGF binds to extracellular matrix proteins - Bos taurus [Reaction:R-CFA-382054] PDGF binds to extracellular matrix proteins - Canis familiaris [Reaction:R-RNO-382054] PDGF binds to extracellular matrix proteins - Rattus norvegicus [Reaction:R-MMU-382054] PDGF binds to extracellular matrix proteins - Mus musculus
output	[Complex:R-HSA-381952] PDGF A and B chains:ECM complex [extracellular region]
precedingEvent	[Reaction:R-HSA-186785] PDGF-AA clevage by Furin - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-382054
summation	[Summation:381882] The long splice version of the PDGF-A chain as well as the C...

Referrals

(hasEvent)

[Pathway:R-HSA-186797] Signaling by PDGF