Reactome | aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate

Schema > Reaction > Entries

aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate Show undefined attributes

authored	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
catalystActivity	[CatalystActivity:379660] aspartate-tRNA ligase activity of DARS2 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:380210] D'Eustachio, P, 2008-11-08 17:23:03
dbId	380229
displayName	aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate
edited	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
eventOf	[Pathway:R-HSA-379726] Mitochondrial tRNA aminoacylation - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-113553] L-Asp [mitochondrial matrix] [GenomeEncodedEntity:R-HSA-379715] tRNA(Asp) [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:380194] Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS [LiteratureReference:389227] Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate
orthologousEvent	[Reaction:R-HSA-380216] glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-380158] cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-380177] alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-380201] threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-380227] asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-380198] proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-380199] valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate - Homo sapiens
output	[SimpleEntity:R-ALL-159448] AMP [mitochondrial matrix] [GenomeEncodedEntity:R-HSA-379698] Asp-tRNA(Asp) [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387428] Antonellis, A, 2008-12-02 16:58:45
revised	[InstanceEdit:389225] D'Eustachio, P, 2008-12-23 21:40:28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-380229
summation	[Summation:380209] DARS2 (mitochondrial aspartyl tRNA synthetase) catalyzes the...
updateTrackers	[UpdateTracker:9791603] Update Tracker - [Reaction:380229] aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate - v28:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791603] Update Tracker - [Reaction:380229] aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate - v28:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-379726] Mitochondrial tRNA aminoacylation