Brevican degradation by MMP1, 2, 3, 7,8,10,13,19

Stable Identifier
R-HSA-3791149
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Brevican, a member of the lectican family, is one of the most abundant proteoglycans in normal adult brain tissues. It is thought to form lattice structures by linking hyaluronan and tenascin-R through its N- and C-terminal globular domains, respectively. As brain extracellular matrix (ECM) contains no collagen fibrils, this matrix of hyaluronan/brevican/tenascin-R is considered essential to maintain the integrity of brain ECM. Degradation of brevican by proteinases disrupts ECM structures and facilitates invasion of glioma cells (Yamaguchi 2000). The major brevican cleavage site observed under physiological conditions (Yamada et al. 1994) and during glioma invasion (Zhang et al. 1998) is the Glu395-Ser396 bond present within the central domain of the core protein, forming an ~50-kDa N-terminal fragment. This bond is cleaved by ADAMTS4 and 5 (Nakamura et al. 2000, Matthews et al. 2000, Nakada et al. 2005). Matrix metalloproteinases that digest brevican (MMP-1, -2, -3, -7, -8, -10, -13 and -19) preferentially cleave the Ala360-Phe361 bond. (Nakamura et al. 2000, Nakada et al. 2005, Lettau et al. 2010).

Literature References
PubMed ID Title Journal Year
10986281 Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites

Nakamura, H, Fujii, Y, Inoki, I, Sugimoto, K, Tanzawa, K, Matsuki, H, Miura, R, Yamaguchi, Y, Okada, Y

J. Biol. Chem. 2000
20142769 Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells

Lettau, I, Hattermann, K, Held-Feindt, J, Brauer, R, Sedlacek, R, Mentlein, R

J. Neuropathol. Exp. Neurol. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MMP1, 2, 3, 7,8,10,13,19 [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created