CCS transfers Cu to SOD1 (mitochondrial)

Stable Identifier
R-HSA-3780979
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
ReviewStatus
5/5
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CCS transfers Cu to SOD1 (mitochondrial)
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As inferred from the cytosolic reaction and from the mitochondrial reaction in mouse, Copper chaperone of superoxide dismutase (CCS) transfers a copper(I) atom to a SOD1 monomer that already contains a Zn atom. After initial heterodimerization between SOD1 and CCS, the copper atom is transferred, intramolecular cysteine disulfide bonds are formed in SOD1, and SOD1 dimerizes.
Participants
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Output
Participates
as an event of
Inferred From
CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Homo sapiens)
Ccs transfers Cu to Sod1 (Mus musculus)
Authored
May, B  (2013-06-27)
Reviewed
Kavdia, M  (2013-11-01)
Created
May, B  (2013-06-28)
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