CCS transfers Cu to SOD1 (mitochondrial)

Stable Identifier
R-HSA-3780979
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
ReviewStatus
5/5
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CCS transfers Cu to SOD1 (mitochondrial)
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As inferred from the cytosolic reaction and from the mitochondrial reaction in mouse, Copper chaperone of superoxide dismutase (CCS) transfers a copper(I) atom to a SOD1 monomer that already contains a Zn atom. After initial heterodimerization between SOD1 and CCS, the copper atom is transferred, intramolecular cysteine disulfide bonds are formed in SOD1, and SOD1 dimerizes.

Participants
Input
Output
Participates
as an event of
Inferred From
CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Homo sapiens)
Ccs transfers Cu to Sod1 (Mus musculus)
Authored
May, B  (2013-06-27)
Reviewed
Kavdia, M  (2013-11-01)
Created
May, B  (2013-06-28)
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