Release of CSK from SRC

Stable Identifier
R-HSA-377644
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Release of CSK from SRC
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CSK bound to integrin alphaIIb beta3 negatively regulates SRC by phosphorylating the Tyr-530. Platelet adhesion to fibrinogen causes the disassociation of CSK from alphaIIb beta3 complex.

Literature References
PubMed ID Title Journal Year
1722201 CSK: a protein-tyrosine kinase involved in regulation of src family kinases

Nakagawa, H, Yamamoto, T, Okada, M, Yamanashi, Y, Nada, S

J Biol Chem 1991
16005629 Integrins and Src: dynamic duo of adhesion signaling

Shattil, SJ

Trends Cell Biol 2005
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Authored
Garapati, P V  (2008-06-16)
Reviewed
Shattil, SJ  (2008-09-16)
Created
Garapati, P V  (2008-09-15)
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