CBY1 binds beta-catenin

Stable Identifier
R-HSA-3769383
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Chibby (CBY1) is a conserved 126 amino acid protein that acts as an antagonist to the canonical WNT signaling pathway. CBY1 binds to the C-terminal region of beta-catenin and inhibits beta-catenin-dependent signaling by competing for the TCF/LEF binding sites and by promoting beta-catenin nuclear export (Takemaru et al, 2003; Li et al, 2008; Li et al, 2010). Endogenous CBY1 and beta-catenin co-immunoprecipitate from HEK293 cells and overexpression of CBY1 reduces expression of a beta-catenin dependent reporter gene, supporting a functional role for the CBY1-beta-catenin interaction in vivo (Takemaru et al, 2003). Studies with CBY1 knockout mice show only a slight effect on expression of WNT-dependent target genes, however; more work will be required to fully elucidate the role of CBY1 in regulating endogenous WNT signaling (Veronina et al, 2009).

Literature References
PubMed ID Title Journal Year
19364920 Inactivation of Chibby affects function of motile airway cilia

Voronina, VA, Takemaru, K, Treuting, P, Love, D, Grubb, BR, Hajjar, AM, Adams, A, Li, FQ, Moon, RT

J. Cell Biol. 2009
12712206 Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway

Takemaru, K, Yamaguchi, S, Lee, YS, Zhang, Y, Carthew, RW, Moon, RT

Nature 2003
18573912 Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity

Li, FQ, Mofunanya, A, Harris, K, Takemaru, K

J. Cell Biol. 2008
19940019 Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling

Li, FQ, Mofunanya, A, Fischer, V, Hall, J, Takemaru, K

Mol. Biol. Cell 2010
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