Receptor CXCR2 binds ligands CXCL1 to 7

Stable Identifier
Homo sapiens
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CXCR2 (High affinity interleukin-8 receptor B) (Murphy PM and Tiffany HL, 1991) is closely related to CXCR1 and binding of IL-8 to the receptor causes activation of neutrophils. Other ELR-positive chemokines (CXCL1 to CXCL7) can also bind with CXCR2 to cause various effects as described below.
CXCL1 (previously known as GRO1 oncogene; NAP-3; MSGA-alpha) (Richmond A et al, 1988) is expressed by neutrophils, macrophages and epithelial cells and possesses neutrophil chemoattractant activity. It is secreted by melanoma cells and is implicated in melanoma pathogenesis. CXCL2 (MIP2-alpha;Gro-beta;Gro-2) (Iida N and Grotendorst GR, 1990; Haskill S et al, 1990) is closely related to CXCL1 (90% amino acid sequence). It is secreted by monocytes and macrophages and attracts polymorphonuclear leukocytes and hematopoietic stem cells. CXCL3 (GRO3; GROg; MIP2-beta) (Haskill S et al, 1990) controls the migration and adhesion of monocytes.
CXCL4 (platelet factor 4, PF4) (Poncz M et al, 1987) is released from platelets during aggregation and promotes blood coagulation by neutralization of heparin-like molecules. It is chemotactic for neutrophils, fibroblasts and monocytes. Due to all these roles, CXCL4 is implicated in wound repair and inflammation. CXCL5 (ENA-78) (Walz A et al, 1991) is produced by cells which have been stimulated by interleulin-1 or tumor necrosis factor-alpha. CXCL7 (pro-platelet basic protein, PPBP) (Holt JC et al, 1986) is released from platelets once they are activated. It can stimulate various processes including glucose metabolism, mitogenesis and syntheses of plasminogen activator and extracellular matrix.

Literature References
PubMed ID Title Journal Year
1744577 Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8

Strieter, RM, Baggiolini, M, Car, B, Walz, A, Burgener, R, Kunkel, SL

J Exp Med 1991
2078213 Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue

Grotendorst, GR, Iida, N

Mol Cell Biol 1990
3098319 Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line

Weiss, MJ, Schwartz, E, Surrey, S, Rappaport, EF, Poncz, M, LaRocco, P, Conway, TM

Blood 1987
2423119 Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin

Holt, AM, Niewiarowski, S, Lange, E, Henschen, A, Holt, JC, Harris, ME

Biochemistry 1986
2217207 Identification of three related human GRO genes encoding cytokine functions

Anisowicz, A, Sporn, SA, Smith, T, Haskill, S, Morris, J, Ralph, P, Peace, A, Lee, SW, Martin, G, Sager, R

Proc Natl Acad Sci U S A 1990
1891716 Cloning of complementary DNA encoding a functional human interleukin-8 receptor

Tiffany, HL, Murphy, PM

Science 1991
2970963 Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin

Spiess, J, Flaggs, G, Thomas, HG, Balentien, E, Barton, DE, Richmond, A, Francke, U, Bordoni, R, Derynck, R

EMBO J 1988
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