Reactome | SEMA4D interacts with Plexin-B1:ErbB2

Schema > Reaction > Entries

SEMA4D interacts with Plexin-B1:ErbB2 Show undefined attributes

authored	[InstanceEdit:399743] Garapati, P V, 2009-03-23 09:59:28
catalystActivity	[CatalystActivity:419656] protein tyrosine kinase activity of Plexin-B1:ErbB2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:373749] Garapati, P V, 2008-07-16 14:41:53
dbId	373750
displayName	SEMA4D interacts with Plexin-B1:ErbB2
edited	[InstanceEdit:399760] Garapati, P V, 2009-03-23 10:00:07
entityOnOtherCell	[Complex:R-HSA-373690] SEMA4D dimer [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-416572] Sema4D induced cell migration and growth-cone collapse - Homo sapiens
followingEvent	[Reaction:R-HSA-416594] LARG and PDZ-RhoGEF binds to Plexin-B1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-419629] Plexin-B1:ErbB2 [plasma membrane] [Complex:R-HSA-373690] SEMA4D dimer [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:419600] ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1 [LiteratureReference:416592] Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SEMA4D interacts with Plexin-B1:ErbB2
orthologousEvent	[Reaction:R-CEL-373750] SEMA4D interacts with Plexin-B1:ErbB2 - Caenorhabditis elegans [Reaction:R-DME-373750] SEMA4D interacts with Plexin-B1:ErbB2 - Drosophila melanogaster [Reaction:R-GGA-373750] SEMA4D interacts with Plexin-B1:ErbB2 - Gallus gallus [Reaction:R-DRE-373750] SEMA4D interacts with Plexin-B1:ErbB2 - Danio rerio [Reaction:R-SSC-373750] SEMA4D interacts with Plexin-B1:ErbB2 - Sus scrofa [Reaction:R-BTA-373750] SEMA4D interacts with Plexin-B1:ErbB2 - Bos taurus [Reaction:R-CFA-373750] SEMA4D interacts with Plexin-B1:ErbB2 - Canis familiaris [Reaction:R-RNO-373750] SEMA4D interacts with Plexin-B1:ErbB2 - Rattus norvegicus [Reaction:R-MMU-373750] SEMA4D interacts with Plexin-B1:ErbB2 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-373695] SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane]
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-373750
summation	[Summation:373610] Sema4D binds Plexin-B1 to induce repulsive or attractive eff...

Referrals

(precedingEvent)	[Reaction:R-HSA-416594] LARG and PDZ-RhoGEF binds to Plexin-B1
(hasEvent)	[Pathway:R-HSA-416572] Sema4D induced cell migration and growth-cone collapse