SEMA4D interacts with Plexin-B1:ErbB2

Stable Identifier
R-HSA-373750
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sema4D binds Plexin-B1 to induce repulsive or attractive effects in neuronal and nonneuronal cells. Plexins constitute a large family of transmembrane proteins that function as receptors for semaphorins and their interaction governs cell adhesion and migration in a variety of tissues. All B-class plexins can interact with the receptor tyrosine kinases Met and ErbB2. Upon binding of Sema4D to plexin-B1, the kinase activity of ErbB2 is increased resulting in tyrosine phosphorylation of both Plexin-B1 and ErbB2. ErbB2 has been shown to mediate Sema4D-induced growth cone collapse in hippocampal neurons by the activation of RhoA via plexinB1 and PDZRhoGEF/LARG.
Sequence alignment reveals the presence of 13 conserved tyrosine residues (highly conserved sites 1918, 1953, 2038) but the specific tyrosine residues phosphorylated in the cytoplasmic domain of plexins in response to semaphorin stimulation have not yet been identified.

Literature References
PubMed ID Title Journal Year
18025083 ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1

Swiercz, JM, Worzfeld, T, Offermanns, S

J Biol Chem 2008
15210733 Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

Swiercz, JM, Kuner, R, Offermanns, S

J Cell Biol 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Plexin-B1:ErbB2 [plasma membrane]
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Activity
Orthologous Events
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