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Entries
Nephrin family interactions
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authored
[InstanceEdit:214881] de Bono, B, Garapati, P V, 2008-02-26 12:30:30
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
dbId
373753
displayName
Nephrin family interactions
doi
10.3180/REACT_23832.1
edited
[InstanceEdit:532602] Garapati, P V, 2010-03-01
eventOf
[TopLevelPathway:R-HSA-1500931] Cell-Cell communication - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-373732] Nephrin trans-homophilic interaction - Homo sapiens
[Reaction:R-HSA-373714] Cis-Heterodimerization of nephrin and KIRREL - Homo sapiens
[Reaction:R-HSA-451757] Heterodimerization of nephrin and KIRREL2, KIRREL3 - Homo sapiens
[Reaction:R-HSA-8981534] Nephrin dimer:KIRREL binds FYN - Homo sapiens
[Reaction:R-HSA-373747] Phosphorylation of nephrin by FYN - Homo sapiens
[Reaction:R-HSA-373724] Nephrin binds NCK - Homo sapiens
[Reaction:R-HSA-532603] Nephrin mediated activation of N-WASP - Homo sapiens
[Reaction:R-HSA-373734] Nephrin interacts with Podocin - Homo sapiens
[Reaction:R-HSA-373727] Nephrin binds CD2AP - Homo sapiens
[Reaction:R-HSA-451758] p85 associates with both p-Nephrin and CD2AP - Homo sapiens
[Reaction:R-HSA-373722] Nephrin binds CASK - Homo sapiens
[Reaction:R-HSA-451377] Interaction of IQGAP1 with nephrin - Homo sapiens
[Reaction:R-HSA-451403] Interaction of nephrin with adherens junction-associated proteins - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:451749] Nephrin--a unique structural and signaling protein of the kidney filter
[LiteratureReference:451745] Nephrin is specifically located at the slit diaphragm of glomerular podocytes
[LiteratureReference:451748] Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm
[LiteratureReference:375810] Hereditary proteinuria syndromes and mechanisms of proteinuria
[LiteratureReference:451753] Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling
[LiteratureReference:936051] The slit diaphragm: a signaling platform to regulate podocyte function
[LiteratureReference:451378] Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex
[LiteratureReference:937359] Genetics of nephrotic syndrome: new insights into molecules acting at the glomerular filtration barrier
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
Nephrin family interactions
orthologousEvent
[Pathway:R-CEL-373753] Nephrin family interactions - Caenorhabditis elegans
[Pathway:R-DME-373753] Nephrin family interactions - Drosophila melanogaster
[Pathway:R-GGA-373753] Nephrin family interactions - Gallus gallus
[Pathway:R-DRE-373753] Nephrin family interactions - Danio rerio
[Pathway:R-SSC-373753] Nephrin family interactions - Sus scrofa
[Pathway:R-BTA-373753] Nephrin family interactions - Bos taurus
[Pathway:R-CFA-373753] Nephrin family interactions - Canis familiaris
[Pathway:R-RNO-373753] Nephrin family interactions - Rattus norvegicus
[Pathway:R-MMU-373753] Nephrin family interactions - Mus musculus
releaseDate
2010-09-21
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:765028] Huber, TB, Grahammer, Florian, 2010-05-20
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-373753
summation
[Summation:375906] Nephrin (NPHS1) is a member of the Super-IgG-Molecule family...
Referrals
(hasEvent)
[TopLevelPathway:R-HSA-1500931] Cell-Cell communication
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