Reactome | AcCho is hydrolyzed to Cho and acetate by ACHE

authored	[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
catalystActivity	[CatalystActivity:1524052] acetylcholinesterase activity of Cholinesterase [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:372526] Mahajan, SS, 2008-06-26 18:29:42
crossReference	[DatabaseIdentifier:12667442] RHEA:17562
dbId	372519
displayName	AcCho is hydrolyzed to Cho and acetate by ACHE
edited	[InstanceEdit:380916] Mahajan, SS, 2008-11-18 00:03:09
eventOf	[Pathway:R-HSA-112311] Neurotransmitter clearance - Homo sapiens [Pathway:R-HSA-1483191] Synthesis of PC - Homo sapiens
followingEvent	[Reaction:R-HSA-444433] Cho transports from the extracellular space to the cytosol - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:19389] acetylcholine catabolic process
input	[SimpleEntity:R-ALL-372533] AcCho [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:372541] Rational design of a drug for Alzheimer's disease with cholinesterase inhibitory and neuroprotective activity [LiteratureReference:1482734] The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant [LiteratureReference:1482716] Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	AcCho is hydrolyzed to Cho and acetate by ACHE Acetylcholine clearance from synaptic cleft
orthologousEvent	[Reaction:R-DDI-372519] AcCho is hydrolyzed to Cho and acetate by ACHE - Dictyostelium discoideum [Reaction:R-CEL-372519] AcCho is hydrolyzed to Cho and acetate by ACHE - Caenorhabditis elegans [Reaction:R-DME-372519] AcCho is hydrolyzed to Cho and acetate by ACHE - Drosophila melanogaster
output	[SimpleEntity:R-ALL-1524044] acetate [extracellular region] [SimpleEntity:R-ALL-264638] Cho [extracellular region]
regulatedBy	[NegativeRegulation:9634836] Negative regulation by 'ACHE:ACHEIs [plasma membrane]'
releaseDate	2008-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-372519
summation	[Summation:373212] Acetylcholinesterase (ACHE) oligomers (comprising monomers, ...
updateTrackers	[UpdateTracker:9788548] Update Tracker - [Reaction:372519] AcCho is hydrolyzed to Cho and acetate by ACHE - v41:[modifyText] [UpdateTracker:9778352] Update Tracker - [Reaction:372519] AcCho is hydrolyzed to Cho and acetate by ACHE - v68:[addRegulator] [UpdateTracker:9788972] Update Tracker - [Reaction:372519] AcCho is hydrolyzed to Cho and acetate by ACHE - v39:[addInput, addLiteratureReference, add_removeCatalystActivity, add_removeOutput, modifyText]

(updatedInstance)	[UpdateTracker:9788548] Update Tracker - [Reaction:372519] AcCho is hydrolyzed to Cho and acetate by ACHE - v41:[modifyText] [UpdateTracker:9778352] Update Tracker - [Reaction:372519] AcCho is hydrolyzed to Cho and acetate by ACHE - v68:[addRegulator] [UpdateTracker:9788972] Update Tracker - [Reaction:372519] AcCho is hydrolyzed to Cho and acetate by ACHE - v39:[addInput, addLiteratureReference, add_removeCatalystActivity, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-1483191] Synthesis of PC [Pathway:R-HSA-112311] Neurotransmitter clearance
(precedingEvent)	[Reaction:R-HSA-444433] Cho transports from the extracellular space to the cytosol

AcCho is hydrolyzed to Cho and acetate by ACHE Show undefined attributes

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