Reactome | AcCho is hydrolyzed to Cho and acetate by ACHE

AcCho is hydrolyzed to Cho and acetate by ACHE

Stable Identifier

R-HSA-372519

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Acetylcholine clearance from synaptic cleft

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

AcCho is hydrolyzed to Cho and acetate by ACHE

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Acetylcholinesterase (ACHE) oligomers (comprising monomers, dimers and tetramers), anchored to the extracellular side of the plasma membrane, hydrolyze acetylcholine (AcCho) to form choline (Cho) and acetate (Weinstock & Groner 2008, Velan et al. 1991, Kryger et al. 2000).

Acetylcholine from the synaptic cleft is degraded into inactive molecules, Cho and acetate by ACHE, which is located in the synaptic cleft (Weinstock & Groner 2008).

Literature References

PubMed ID	Title	Journal	Year
1748670	The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant Velan, B, Grosfeld, H, Kronman, C, Leitner, M, Gozes, Y, Lazar, A, Flashner, Y, Marcus, D, Cohen, S, Shafferman, A	J Biol Chem	1991
11053835	Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II Kryger, G, Harel, M, Giles, K, Toker, L, Velan, B, Lazar, A, Kronman, C, Barak, D, Ariel, N, Shafferman, A, Silman, I, Sussman, JL	Acta Crystallogr D Biol Crystallogr	2000
18457821	Rational design of a drug for Alzheimer's disease with cholinesterase inhibitory and neuroprotective activity Weinstock, M, Groner, E	Chem Biol Interact	2008