AcCho is hydrolyzed to Cho and acetate by ACHE

Stable Identifier
R-HSA-372519
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Acetylcholine clearance from synaptic cleft
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Acetylcholinesterase (ACHE) oligomers (comprising monomers, dimers and tetramers), anchored to the extracellular side of the plasma membrane, hydrolyze acetylcholine (AcCho) to form choline (Cho) and acetate (Weinstock & Groner 2008, Velan et al. 1991, Kryger et al. 2000).

Acetylcholine from the synaptic cleft is degraded into inactive molecules, Cho and acetate by ACHE, which is located in the synaptic cleft (Weinstock & Groner 2008).

Literature References
PubMed ID Title Journal Year
1748670 The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant

Velan, B, Grosfeld, H, Kronman, C, Leitner, M, Gozes, Y, Lazar, A, Flashner, Y, Marcus, D, Cohen, S, Shafferman, A

J Biol Chem 1991
11053835 Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

Kryger, G, Harel, M, Giles, K, Toker, L, Velan, B, Lazar, A, Kronman, C, Barak, D, Ariel, N, Shafferman, A, Silman, I, Sussman, JL

Acta Crystallogr D Biol Crystallogr 2000
18457821 Rational design of a drug for Alzheimer's disease with cholinesterase inhibitory and neuroprotective activity

Weinstock, M, Groner, E

Chem Biol Interact 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acetylcholinesterase activity of Cholinesterase [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created