Acetylcholinesterase (ACHE) oligomers (comprising monomers, dimers and tetramers), anchored to the extracellular side of the plasma membrane, hydrolyze acetylcholine (AcCho) to form choline (Cho) and acetate (Weinstock & Groner 2008, Velan et al. 1991, Kryger et al. 2000).Acetylcholine from the synaptic cleft is degraded into inactive molecules, Cho and acetate by ACHE, which is located in the synaptic cleft (Weinstock & Groner 2008).
Velan, B, Grosfeld, H, Kronman, C, Leitner, M, Gozes, Y, Lazar, A, Flashner, Y, Marcus, D, Cohen, S, Shafferman, A
Kryger, G, Harel, M, Giles, K, Toker, L, Velan, B, Lazar, A, Kronman, C, Barak, D, Ariel, N, Shafferman, A, Silman, I, Sussman, JL
Weinstock, M, Groner, E
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