SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane

Stable Identifier
R-HSA-352379
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane
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SLC1A5, associated with the plasma membrane, mediates the exchange of extracellular alanine for cytosolic glutamine (Broer et al. 2000).

Literature References
PubMed ID Title Journal Year
10698697 Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance

Broer, A, Wagner, CA, Lang, F, Broer, S

Biochem J 2000
8702519 Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line

Kekuda, R, Prasad, PD, Fei, YJ, Torres-Zamorano, V, Sinha, S, Yang-Feng, TL, Leibach, FH, Ganapathy, V

J Biol Chem 1996
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Event Information
Reverse Reaction
SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Homo sapiens)
Catalyst Activity

amino acid transmembrane transporter activity of SLC1A5 [plasma membrane]

Physical Entity
SLC1A5 [plasma membrane] (Homo sapiens)
Activity
amino acid transmembrane transporter activity (GO:0015171)
Orthologous Events
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Caenorhabditis elegans)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Canis familiaris)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Danio rerio)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Drosophila melanogaster)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Mus musculus)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Rattus norvegicus)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Sus scrofa)
Authored
D'Eustachio, P  (2008-06-03)
Reviewed
Jassal, B  (2008-06-03)
Created
D'Eustachio, P  (2008-06-03)
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