SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane

Stable Identifier
R-HSA-352379
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane
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SLC1A5, associated with the plasma membrane, mediates the exchange of extracellular alanine for cytosolic glutamine (Broer et al. 2000).
Literature References
PubMed ID Title Journal Year
8702519 Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line

Leibach, FH, Torres-Zamorano, V, Ganapathy, V, Yang-Feng, TL, Sinha, S, Prasad, PD, Fei, YJ, Kekuda, R

J Biol Chem 1996
10698697 Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance

Broer, A, Lang, F, Wagner, CA, Broer, S

Biochem J 2000
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Event Information
Reverse Reaction
SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Homo sapiens)
Catalyst Activity

amino acid transmembrane transporter activity of SLC1A5 [plasma membrane]

Physical Entity
SLC1A5 [plasma membrane] (Homo sapiens)
Activity
amino acid transmembrane transporter activity (GO:0015171)
Orthologous Events
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Bos taurus)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Caenorhabditis elegans)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Canis familiaris)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Danio rerio)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Drosophila melanogaster)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Mus musculus)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Rattus norvegicus)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Sus scrofa)
SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Xenopus tropicalis)
Authored
D'Eustachio, P  (2008-06-03)
Reviewed
Jassal, B  (2008-06-03)
Created
D'Eustachio, P  (2008-06-03)
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