SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine

Stable Identifier
Reaction [transition]
Homo sapiens
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SLC1A4, associated with the plasma membrane, mediates the exchange of serine and an extracellular sodium ion for a cytosolic sodium ion and any one of the four amino acids alanine, serine, threonine, or cysteine (Zerangue and Kavanaugh 1996).

Literature References
PubMed ID Title Journal Year
8101838 Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family

Wu, YN, Murdoch, GH, Arriza, JL, Amara, SG, North, RA, Kavanaugh, MP, Fairman, WA

J Biol Chem 1993
8910405 ASCT-1 is a neutral amino acid exchanger with chloride channel activity

Zerangue, N, Kavanaugh, MP

J Biol Chem 1996
8340364 Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters

Shafqat, S, Kilberg, MS, Puranam, RS, Tamarappoo, BK, McNamara, JO, Fremeau RT, Jr, GuadaƱo-Ferraz, A

J Biol Chem 1993
Catalyst Activity

amino acid transmembrane transporter activity of SLC1A4 [plasma membrane]

Orthologous Events
Cross References
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