Cleavage of Satb1

Stable Identifier
R-HSA-352268
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cleavage of Satb1
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Cleaved Satb1 dissociates from chromatin and may function in high molecular weight DNA fragmentation (Galande et al., 2001).

Literature References
PubMed ID Title Journal Year
11463840 SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis

Sikorska, M, Mian, IS, Galande, S, Dickinson, LA, Kohwi-Shigematsu, T

Mol Cell Biol 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of active caspase-6 [nucleoplasm]

Physical Entity
active caspase-6 [nucleoplasm] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Cleavage of Satb1 (Bos taurus)
Cleavage of Satb1 (Canis familiaris)
Cleavage of Satb1 (Danio rerio)
Cleavage of Satb1 (Drosophila melanogaster)
Cleavage of Satb1 (Gallus gallus)
Cleavage of Satb1 (Mus musculus)
Cleavage of Satb1 (Rattus norvegicus)
Cleavage of Satb1 (Sus scrofa)
Cleavage of Satb1 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-06-02)
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