PIAS1,3,4 SUMOylate MTA1 with SUMO2,3

Stable Identifier
R-HSA-3465545
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS1,3,4 SUMOylate MTA1 with SUMO2,3
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PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 at lysine-509 (Cong et al. 2011). SUMOylation increases the repressor activity of MTA1 at the PS2 promoter (Cong et al. 2011).
Literature References
PubMed ID Title Journal Year
21965678 SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function

Ohshiro, K, Kumar, R, Pakala, SB, Cong, L, Li, DQ

J. Biol. Chem. 2011
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein sumoylation (0016925)
Catalyst Activity

SUMO transferase activity of PIAS1,3,4 [nucleoplasm]

Physical Entity
PIAS1,3,4 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Bos taurus)
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Drosophila melanogaster)
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Gallus gallus)
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Mus musculus)
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Rattus norvegicus)
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Sus scrofa)
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Xenopus tropicalis)
Authored
May, B  (2013-05-16)
Reviewed
Kumar, R  (2015-10-10)
Created
May, B  (2013-05-17)
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