Reactome | TNF-? trimer, soluble form [extracellular region]

Schema > Complex > Entries

TNF-? trimer, soluble form [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-9714968] TNF-alpha inhibitors:TNF-alpha trimer, soluble form [extracellular region] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-3371353] Soluble TNF-? binds TNFR1 - Homo sapiens [Reaction:R-HSA-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Homo sapiens
created	[InstanceEdit:3371404] Shamovsky, V, 2013-05-13
dbId	3371370
displayName	TNF-? trimer, soluble form [extracellular region]
hasComponent	3 × [EntityWithAccessionedSequence:R-HSA-976821] TNF(77-233) [extracellular region]
inDisease	false
inferredTo	[Complex:R-MMU-3371370] TNF-? trimer, soluble form [extracellular region] - Mus musculus [Complex:R-RNO-3371370] TNF-? trimer, soluble form [extracellular region] - Rattus norvegicus [Complex:R-CFA-3371370] TNF-? trimer, soluble form [extracellular region] - Canis familiaris [Complex:R-BTA-3371370] TNF-? trimer, soluble form [extracellular region] - Bos taurus [Complex:R-SSC-3371370] TNF-? trimer, soluble form [extracellular region] - Sus scrofa [Complex:R-DRE-3371370] TNF-? trimer, soluble form [extracellular region] - Danio rerio [Complex:R-XTR-3371370] TNF-? trimer, soluble form [extracellular region] - Xenopus tropicalis
isChimeric	false
literatureReference	[LiteratureReference:3371402] The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding
maxDepth	2
modified	[InstanceEdit:9794238] Shamovsky, Veronica, 2022-06-30
name	TNF-? trimer, soluble form TNF-alpha trimer
producedByEvent	[Reaction:R-HSA-3371385] TNF-? is cleaved by ADAM17 (TACE) - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-3371370
updateTrackers	[UpdateTracker:9904383] Update Tracker - [Complex:3371370] TNF-? trimer, soluble form [extracellular region] - v82:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9904383] Update Tracker - [Complex:3371370] TNF-? trimer, soluble form [extracellular region] - v82:[modifyName]
(hasComponent)	[Complex:R-HSA-9714968] TNF-alpha inhibitors:TNF-alpha trimer, soluble form [extracellular region] [Complex:R-HSA-3371397] soluble TNF-?:TNFR1 [plasma membrane]
(input)	[Reaction:R-HSA-9714924] TNF-alpha inhibitors bind to soluble TNF trimer [Reaction:R-HSA-3371353] Soluble TNF-? binds TNFR1
(output)	[Reaction:R-HSA-3371385] TNF-? is cleaved by ADAM17 (TACE)

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