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About
What is Reactome ?
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Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
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Digital Preservation
Contact us
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Table of Contents
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TNF-α trimer, soluble form [extracellular region]
Stable Identifier
R-HSA-3371370
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
TNF-alpha trimer
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Homo sapiens)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
OPTN recruits CYLD to the TNFR1 complex (Homo sapiens)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1 binds DENN/MADD (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:DENN-SV,MADD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Homo sapiens)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
Soluble TNF-α binds TNFR1 (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha inhibitors bind to soluble TNF trimer (Homo sapiens)
TNF-alpha inhibitors:TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α is cleaved by ADAM17 (TACE) (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNFR1-induced NF-kappa-B signaling pathway (Homo sapiens)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNFR1-mediated ceramide production (Homo sapiens)
TNF-α:TNFR1 binds NSMAF (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)
TNF-α:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1:SMPD2,3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
2551905
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding
Eck, MJ
,
Sprang, SR
J. Biol. Chem.
1989
Participants
components
x 3
TNF(77-233) [extracellular region]
(Homo sapiens)
Participates
as a component of
TNF-alpha inhibitors:TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
as an input of
TNF-alpha inhibitors bind to soluble TNF trimer (Homo sapiens)
Soluble TNF-α binds TNFR1 (Homo sapiens)
as an output of
TNF-α is cleaved by ADAM17 (TACE) (Homo sapiens)
Inferred To
TNF-α trimer, soluble form [extracellular region]
(Bos taurus)
TNF-α trimer, soluble form [extracellular region]
(Canis familiaris)
TNF-α trimer, soluble form [extracellular region]
(Danio rerio)
TNF-α trimer, soluble form [extracellular region]
(Mus musculus)
TNF-α trimer, soluble form [extracellular region]
(Rattus norvegicus)
TNF-α trimer, soluble form [extracellular region]
(Sus scrofa)
TNF-α trimer, soluble form [extracellular region]
(Xenopus tropicalis)
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