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TNF-alpha trimer, soluble form [extracellular region]
Stable Identifier
R-HSA-3371370
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
TNF-alpha trimer
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
RIPK1 is deubiquitinated (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1 binds DENN/MADD (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:DENN-SV,MADD [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Homo sapiens)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
Soluble TNF-alpha binds TNFR1 (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha is cleaved by ADAM17 (TACE) (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNFR1-induced NFkappaB signaling pathway (Homo sapiens)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNFalpha:TNF-R1:TRADD:K63polyUb-RIP1:BIRC2/3:IKKA:IKKB:NEMO [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNFR1-mediated ceramide production (Homo sapiens)
TNF-alpha:TNFR1 binds NSMAF (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)
TNF-alpha:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1:SMPD2,3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-alpha trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-alpha:TNFR1 [plasma membrane] (Homo sapiens)
TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
2551905
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding
Eck, MJ
,
Sprang, SR
J. Biol. Chem.
1989
Participants
components
3 x
TNF(77-233) [extracellular region] (Homo sapiens)
Participant Of
output
TNF-alpha is cleaved by ADAM17 (TACE)
input
Soluble TNF-alpha binds TNFR1
hasComponent
soluble TNF-alpha:TNFR1 [plasma membrane]
Inferred To
TNF-alpha trimer, soluble form [extracellular region] (Bos taurus)
TNF-alpha trimer, soluble form [extracellular region] (Canis familiaris)
TNF-alpha trimer, soluble form [extracellular region] (Danio rerio)
TNF-alpha trimer, soluble form [extracellular region] (Mus musculus)
TNF-alpha trimer, soluble form [extracellular region] (Rattus norvegicus)
TNF-alpha trimer, soluble form [extracellular region] (Sus scrofa)
TNF-alpha trimer, soluble form [extracellular region] (Xenopus tropicalis)
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