Reactome | TNF-? trimer, soluble form [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-DRE-9714968] TNF-alpha inhibitors:TNF-alpha trimer, soluble form [extracellular region] - Danio rerio
consumedByEvent	[Reaction:R-DRE-3371353] Soluble TNF-? binds TNFR1 - Danio rerio [Reaction:R-DRE-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10565719
displayName	TNF-? trimer, soluble form [extracellular region]
hasComponent	3 × [EntityWithAccessionedSequence:R-DRE-976821] tnfa [extracellular region]
inDisease	false
inferredFrom	[Complex:R-HSA-3371370] TNF-? trimer, soluble form [extracellular region] - Homo sapiens
maxDepth	2
name	TNF-? trimer, soluble form
producedByEvent	[Reaction:R-DRE-3371385] TNF-? is cleaved by ADAM17 (TACE) - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-3371370
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DRE-9714924] TNF-alpha inhibitors bind to soluble TNF trimer [Reaction:R-DRE-3371353] Soluble TNF-? binds TNFR1
(hasComponent)	[Complex:R-DRE-9714968] TNF-alpha inhibitors:TNF-alpha trimer, soluble form [extracellular region] [Complex:R-DRE-3371397] soluble TNF-?:TNFR1 [plasma membrane]
(output)	[Reaction:R-DRE-3371385] TNF-? is cleaved by ADAM17 (TACE)
(inferredTo)	[Complex:R-HSA-3371370] TNF-? trimer, soluble form [extracellular region]

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