Reactome | GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

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GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O Show undefined attributes

authored	[InstanceEdit:3323087] May, B, 2013-05-09
catalystActivity	[CatalystActivity:3322984] glutathione peroxidase activity of GPX1 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:3323020] May, B, 2013-05-09
crossReference	[DatabaseIdentifier:12667839] RHEA:16834
dbId	3323013
displayName	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
edited	[InstanceEdit:3323087] May, B, 2013-05-09
eventOf	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species - Homo sapiens
followingEvent	[Reaction:R-HSA-3323079] GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Homo sapiens
input	2 × [SimpleEntity:R-ALL-1655887] GSH [mitochondrial matrix] [SimpleEntity:R-ALL-1614617] H2O2 [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3323080] Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells [LiteratureReference:3343681] The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase [LiteratureReference:3343666] Overexpression of cytosolic glutathione peroxidase (GPX1) delays endothelial cell growth and increases resistance to toxic challenges [LiteratureReference:9717162] Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function [LiteratureReference:9717165] ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
orthologousEvent	[Reaction:R-CEL-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Caenorhabditis elegans [Reaction:R-GGA-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Gallus gallus [Reaction:R-XTR-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Xenopus tropicalis [Reaction:R-SSC-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Sus scrofa [Reaction:R-BTA-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Bos taurus [Reaction:R-CFA-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Canis familiaris [Reaction:R-RNO-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Rattus norvegicus [Reaction:R-MMU-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Mus musculus
output	[SimpleEntity:R-ALL-1655882] GSSG [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-3299680] SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4837339] Kavdia, Mahendra, 2013-11-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3323013
summation	[Summation:3343737] Glutathione peroxidase 1 (GPX1) located in the mitochondrial...
updateTrackers	[UpdateTracker:9776204] Update Tracker - [Reaction:3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - v77:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776204] Update Tracker - [Reaction:3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - v77:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species
(precedingEvent)	[Reaction:R-HSA-3323079] GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

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