GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
R-HSA-3323013
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
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Glutathione peroxidase 1 (GPX1) located in the mitochondrial matrix (Bera et al. 2014) uses glutathione to reduce hydrogen peroxide (H2O2) to yield oxidized glutathione and water (Legault et al. 2000, Li et al. 2000, Faucher et al. 2003, Lu et al. 2012). As inferred from rat mitochondria, GPX1 is the major determinant of steady-state hydrogen peroxide levels (Antunes et al. 2002).
Literature References
PubMed ID Title Journal Year
25047527 Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function

Bonini, MG, Weinberg, F, Mao, M, Diamond, AM, Ekoue, DN, Bera, S, Ansenberger-Fricano, K

Cancer Res 2014
10833429 Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells

Mirault, ME, Petrov, P, Carrier, C, Legault, J, Renard, P, Remacle, J

Biochem. Biophys. Res. Commun. 2000
23152058 ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction

Luo, Y, Huang, P, Chen, Z, Lu, W, Zhang, H, Wang, Y

Cell Death Dis 2012
10919671 The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase

Yang, JQ, Li, S, Yan, T, Oberley, LW, Oberley, TD

Cancer Res. 2000
12829378 Overexpression of cytosolic glutathione peroxidase (GPX1) delays endothelial cell growth and increases resistance to toxic challenges

Barrière, G, Cook-Moreau, J, Faucher, K, Rigaud, M, Rabinovitch-Chable, H

Biochimie 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glutathione peroxidase activity of GPX1 tetramer [mitochondrial matrix]

Physical Entity
GPX1 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
glutathione peroxidase activity (GO:0004602)
Orthologous Events
GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)
GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
Cross References
Rhea
Authored
May, B  (2013-05-09)
Reviewed
Kavdia, M  (2013-11-01)
Created
May, B  (2013-05-09)
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