Reactome | GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier

R-HSA-3323013

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

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GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

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Glutathione peroxidase 1 (GPX1) located in the mitochondrial matrix uses glutathione to reduce hydrogen peroxide (H2O2) to yield oxidized glutathione and water (Legault et al. 2000, Li et al. 2000, Faucher et al. 2003). As inferred from rat mitochondria, GPX1 is the major determinant of steady-state hydrogen peroxide levels (Antunes et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12398934	Relative contributions of heart mitochondria glutathione peroxidase and catalase to H(2)O(2) detoxification in in vivo conditions Antunes, F, Han, D, Cadenas, E	Free Radic. Biol. Med.	2002
10833429	Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells Legault, J, Carrier, C, Petrov, P, Renard, P, Remacle, J, Mirault, ME	Biochem. Biophys. Res. Commun.	2000
10919671	The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase Li, S, Yan, T, Yang, JQ, Oberley, TD, Oberley, LW	Cancer Res.	2000
12829378	Overexpression of cytosolic glutathione peroxidase (GPX1) delays endothelial cell growth and increases resistance to toxic challenges Faucher, K, Rabinovitch-Chable, H, Barrière, G, Cook-Moreau, J, Rigaud, M	Biochimie	2003