Glutathione peroxidase 1 (GPX1) located in the mitochondrial matrix (Bera et al. 2014) uses glutathione to reduce hydrogen peroxide (H2O2) to yield oxidized glutathione and water (Legault et al. 2000, Li et al. 2000, Faucher et al. 2003, Lu et al. 2012). As inferred from rat mitochondria, GPX1 is the major determinant of steady-state hydrogen peroxide levels (Antunes et al. 2002).
Bonini, MG, Weinberg, F, Mao, M, Diamond, AM, Ekoue, DN, Bera, S, Ansenberger-Fricano, K
Mirault, ME, Petrov, P, Carrier, C, Legault, J, Renard, P, Remacle, J
Luo, Y, Huang, P, Chen, Z, Lu, W, Zhang, H, Wang, Y
Yang, JQ, Li, S, Yan, T, Oberley, LW, Oberley, TD
Barrière, G, Cook-Moreau, J, Faucher, K, Rigaud, M, Rabinovitch-Chable, H
glutathione peroxidase activity of GPX1 tetramer [mitochondrial matrix]
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