Reactome | CALM1:Ca2+ binds CNG channel

CALM1:Ca2+ binds CNG channel

Stable Identifier

R-HSA-3229181

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Calmodulin:Ca2+ lowers CNG channel sensitivity to cGMP

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Visual phototransduction (Homo sapiens)
        
        The phototransduction cascade (Homo sapiens)
        
        Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
        
        CALM1:Ca2+ binds CNG channel (Homo sapiens)

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As the channels reopen, rising Ca2+ levels result in binding of Ca2+ to calmodulin (CALM1). By targeting the beta subunit of the channel, CALM1:Ca2+ reduces the apparent affinity of the channel for cGMP (Chen et al. 1994, Hsu & Molday 1993, Hsu & Molday 1994).

Literature References

PubMed ID	Title	Journal	Year
7678445	Modulation of the cGMP-gated channel of rod photoreceptor cells by calmodulin. Hsu, YT, Molday, RS	Nature	1993
7525588	Interaction of calmodulin with the cyclic GMP-gated channel of rod photoreceptor cells. Modulation of activity, affinity purification, and localization Hsu, YT, Molday, RS	J. Biol. Chem.	1994
7526403	Subunit 2 (or beta) of retinal rod cGMP-gated cation channel is a component of the 240-kDa channel-associated protein and mediates Ca(2+)-calmodulin modulation. Chen, TY, Illing, M, Molday, LL, Hsu, YT, Yau, KW, Molday, RS	Proc Natl Acad Sci U S A	1994