As the channels reopen, rising Ca2+ levels result in binding of Ca2+ to calmodulin (CALM1). By targeting the beta subunit of the channel, CALM1:Ca2+ reduces the apparent affinity of the channel for cGMP (Chen et al. 1994, Hsu & Molday 1993, Hsu & Molday 1994).
Hsu, YT, Molday, RS
Chen, TY, Illing, M, Molday, LL, Hsu, YT, Yau, KW, Molday, RS
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