Reactome | PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter

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PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3229109] Orlic-Milacic, M, 2013-03-26
dbId	3229089
displayName	PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-3229102] p-MAPKAPK3 phosphorylates BMI1 - Homo sapiens
input	[Complex:R-HSA-3222570] CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] [Complex:R-HSA-3229073] PRC1.4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3229074] PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes [LiteratureReference:3229104] MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1 [LiteratureReference:3229093] Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus [LiteratureReference:3229107] Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter
orthologousEvent	[Reaction:R-DME-3229089] PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter - Drosophila melanogaster [Reaction:R-GGA-3229089] PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter - Gallus gallus [Reaction:R-XTR-3229089] PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter - Xenopus tropicalis [Reaction:R-DRE-3229089] PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter - Danio rerio [Reaction:R-SSC-3229089] PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter - Sus scrofa [Reaction:R-BTA-3229089] PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter - Bos taurus [Reaction:R-CFA-3229089] PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter - Canis familiaris [Reaction:R-RNO-3229089] PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter - Rattus norvegicus
output	[Complex:R-HSA-3229098] CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3229089
summation	[Summation:3769470] PRC1.4 complex, which includes PCGF4 (BMI1), RING1 (RING1A) ...

Referrals

(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[Reaction:R-HSA-3229102] p-MAPKAPK3 phosphorylates BMI1