PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter

Stable Identifier
R-HSA-3229089
Type
Reaction [binding]
Species
Homo sapiens
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PRC1.4 complex, which includes PCGF4 (BMI1), RING1 (RING1A) and RNF2 (RING1B) ubiquitin ligases and CBX proteins (Gao et al. 2012), binds nucleosomes trimethylated on the lysine residue 28 of histone H3 (Me3K-28-HIST1H3A, also known as H3K27Me3), located on CDKN2A promoter (Dietrich et al. 2007, Agherbi et al. 2009, Voncken et al. 2005), through interaction of BMI1 and CBX proteins with Me3K-28-HIST1H3A mark (Gao et al. 2012, Dietrich et al. 2007).

Literature References
PubMed ID Title Journal Year
22325352 PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes

Gao, Z, Zhang, J, Bonasio, R, Strino, F, Sawai, A, Parisi, F, Kluger, Y, Reinberg, D

Mol. Cell 2012
17332741 Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus

Dietrich, N, Bracken, AP, Trinh, E, Schjerling, CK, Koseki, H, Rappsilber, J, Helin, K, Hansen, KH

EMBO J. 2007
19462008 Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence

Agherbi, H, Gaussmann-Wenger, A, Verthuy, C, Chasson, L, Serrano, M, Djabali, M

PLoS ONE 2009
15563468 MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1

Voncken, JW, Niessen, H, Neufeld, B, Rennefahrt, U, Dahlmans, V, Kubben, N, Holzer, B, Ludwig, S, Rapp, UR

J. Biol. Chem. 2005
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