Reactome | PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter

PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter

Stable Identifier

R-HSA-3229089

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PRC1.4 complex, which includes PCGF4 (BMI1), RING1 (RING1A) and RNF2 (RING1B) ubiquitin ligases and CBX proteins (Gao et al. 2012), binds nucleosomes trimethylated on the lysine residue 28 of histone H3 (Me3K-28-HIST1H3A, also known as H3K27Me3), located on CDKN2A promoter (Dietrich et al. 2007, Agherbi et al. 2009, Voncken et al. 2005), through interaction of BMI1 and CBX proteins with Me3K-28-HIST1H3A mark (Gao et al. 2012, Dietrich et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17332741	Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus Dietrich, N, Bracken, AP, Trinh, E, Schjerling, CK, Koseki, H, Rappsilber, J, Helin, K, Hansen, KH	EMBO J.	2007
22325352	PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes Gao, Z, Zhang, J, Bonasio, R, Strino, F, Sawai, A, Parisi, F, Kluger, Y, Reinberg, D	Mol. Cell	2012
19462008	Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence Agherbi, H, Gaussmann-Wenger, A, Verthuy, C, Chasson, L, Serrano, M, Djabali, M	PLoS ONE	2009
15563468	MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1 Voncken, JW, Niessen, H, Neufeld, B, Rennefahrt, U, Dahlmans, V, Kubben, N, Holzer, B, Ludwig, S, Rapp, UR	J. Biol. Chem.	2005