Reactome | ERK1/2-activated AP1 complex binds KDM6B promoter

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ERK1/2-activated AP1 complex binds KDM6B promoter Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3222537] Orlic-Milacic, M, 2013-03-22
dbId	3222533
displayName	ERK1/2-activated AP1 complex binds KDM6B promoter
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3222546] AP-1 complex stimulates KDM6B transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3222526] KDM6B Gene [nucleoplasm] [Complex:R-HSA-450327] p-2S-cJUN:p-2S,2T-cFOS [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3222540] Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis [LiteratureReference:3222541] The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence [LiteratureReference:3222596] The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERK1/2-activated AP1 complex binds KDM6B promoter
output	[Complex:R-HSA-3222535] p-2S-cJUN:p-2S,2T-cFOS:KDM6B Gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3222533
summation	[Summation:3772123] Binding of the AP-1 (JUN:FOS) subunit JUN to the KDM6B (JMJD...

Referrals

(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[BlackBoxEvent:R-HSA-3222546] AP-1 complex stimulates KDM6B transcription

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