ERK1/2-activated AP1 complex binds KDM6B promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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Binding of the AP-1 (JUN:FOS) subunit JUN to the KDM6B (JMJD3) promoter, as well as the transcription of KDM6B gene increases after ERK activation (Lin et al. 2012).

Literature References
PubMed ID Title Journal Year
19451217 The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

Agger, K, Cloos, PA, Rudkjaer, L, Williams, K, Andersen, G, Christensen, J, Helin, K

Genes Dev. 2009
22020331 Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis

Lin, TY, Cheng, YC, Yang, HC, Lin, WC, Wang, CC, Lai, PL, Shieh, SY

Oncogene 2012
17825402 The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

De Santa, F, Totaro, MG, Prosperini, E, Notarbartolo, S, Testa, G, Natoli, G

Cell 2007
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