Reactome | NUAK1 phosphorylates TP53

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NUAK1 phosphorylates TP53 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:3222019] protein serine/threonine kinase activity of TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3222018] Orlic-Milacic, M, 2013-03-18
dbId	3222020
displayName	NUAK1 phosphorylates TP53
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens
input	8 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-6805037] TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3222010] A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	NUAK1 phosphorylates TP53
orthologousEvent	[Reaction:R-SSC-3222020] NUAK1 phosphorylates TP53 - Sus scrofa [Reaction:R-BTA-3222020] NUAK1 phosphorylates TP53 - Bos taurus [Reaction:R-CFA-3222020] NUAK1 phosphorylates TP53 - Canis familiaris [Reaction:R-RNO-3222020] NUAK1 phosphorylates TP53 - Rattus norvegicus [Reaction:R-MMU-3222020] NUAK1 phosphorylates TP53 - Mus musculus
output	8 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-3222017] p-S15,S392-TP53 Tetramer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3222011] p-T211-NUAK1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-164119] STK11 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3222006] STK11 (LKB1) phosphorylates NUAK1 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3222020
summation	[Summation:6805041] NUAK1, activated by STK11 (LKB1)-mediated phosphorylation on...

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(hasEvent)

[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation

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