Reactome | ERF binds ETS2 promoter

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ERF binds ETS2 promoter Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3209180] Orlic-Milacic, M, 2013-03-01
dbId	3209177
displayName	ERF binds ETS2 promoter
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3209179] ERF inhibits ETS2 expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2534321] ERF [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3209178] ETS2 Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3209175] ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation [LiteratureReference:3209161] ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERF binds ETS2 promoter
output	[Complex:R-HSA-3209182] ERF:ETS2 Gene [nucleoplasm]
regulatedBy	[NegativeRegulation:R-HSA-8979075] Negative regulation by 'p-T,Y MAPK dimers [nucleoplasm]'
regulationReference	[RegulationReference:9642057] Negative regulation by 'p-T,Y MAPK dimers [nucleoplasm]' ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3209177
summation	[Summation:3245932] ERF binds to an ETS-binding site in the ETS2 promoter (Sgour...
updateTrackers	[UpdateTracker:9781835] Update Tracker - [Reaction:3209177] ERF binds ETS2 promoter - v60:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781835] Update Tracker - [Reaction:3209177] ERF binds ETS2 promoter - v60:[addLiteratureReference, addRegulator, modifyText]
(precedingEvent)	[BlackBoxEvent:R-HSA-3209179] ERF inhibits ETS2 expression
(hasEvent)	[Pathway:R-HSA-2559585] Oncogene Induced Senescence